摘要
本实验室曾报道,六味地黄煎剂对小鼠实验性肝损伤有保护作用,能显著降低CCl_4中毒小鼠及硫代乙酰胺引起的小鼠谷丙转氨酶活性升高。为进一步探讨六味地黄配方组成的合理性及其与保肝作用关系,本实验考察了其拆方后“三补”、“三泻”对小鼠SGPT活性升高的影响。
It was reported that Liuwei Dihuang Decoction, an ancient Chinese traditional recipe lessened obviously the chemical-intoxicated liver injury. The recipe consists of six medicinal herbs. To investigate the relationship between fundamentals of the formulation and pharmacological activity, we divided the recipe into two parts: 'three tonics' (Radix Rehmanniae Preparata, Fructus Corni. Rhizoma Dioscoreae) and 'three purgatives' (Poria, Cortex Moutan Radicis, Rhizoma Alismatis). It was found that both 'three tonics' and 'three purgatives' could not inhibit the elevated SGPT activity induced by CCl_4 and thioacetamide as the whole recipe did. Furthermore, four mice died four days after treatment with 'three tonics'. The results indicated that neither 'three tonics' nor 'three purgatives' had protective effect on the liver function and the toxicity of 'three tonics' may be greater than that of the the whole recipe. These experiments revealed that the ingredients of Liuwei Dihuang Decoction is proved to be reasonable. The efficacy of the formulation depends on the combined six herbs instead of the separate components.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1990年第4期244-245,共2页
Journal of China Pharmaceutical University
关键词
六味地黄煎剂
小鼠
药理
肝损伤
Liuwei Dihuang Decoction
Three tonics
Three purgatives
Liver injury
SGPT
