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六味地黄煎剂研究 Ⅰ.全方及拆方对小鼠耐缺氧与降血脂的作用 被引量:25

Study on Liuwei Dihuang Decoction Ⅰ.Antihypoxia and Hypolipid Effects of Whole and Partial Recipes in Mice
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摘要 传统中医理论认为六味地黄方是以肝肾之阴为主的补阴代表方剂,方中以熟地,山茱萸,山药为补肝、肾、脾三阴之药,简称“三补”,以泽泻,丹皮,茯苓为“三泻”。 The antihypoxia, hypolipid of Liuwei Dihuang Decoction (LD) and partial recipes (PR_(?)) were studied. The results showed that 20, 29 ml / kg, po of LD could antagonize hypoxia in mice significantly. At higher dose (29 ml / kg, po) LD also had antihypoxia action in mice with the pretreatment of isoproterenol. All PR_(?) had no effect on antihypoxia. LD (20 mg/kg, po Bid) and PR_2 (Cortex Moutan Radicis, Poria, Rhizoma Alismatis), PR_3 (Rhizoma Alismatis, Radix Rehmanniae Preparata) and PR_4 (Fruclus Corni, Cortex Moutan Radicis) decreased total cholesterol (TC) levels of the experiment hyperlipidemia and increased siginificantly (HCL-C) / TC in mice, namely high density lipoprotein cholesterol (HDL-C) was relatively elevated. LD and all PR_(?) showed no effect on the weights of spleen and liver, but LD and PR_1 (Radix Rehmanniae Preparata, Fructus Corni, Rhizoma Dioscoreae) and PR_3 decreased the fat content in the liver.
出处 《中国药科大学学报》 CAS CSCD 北大核心 1990年第4期241-243,共3页 Journal of China Pharmaceutical University
关键词 六味地黄煎剂 药理 小鼠 降血脂 Luiwei Dihuang Decoction Antihypoxia Hypolipid Partial recipes
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  • 1黄正良.某些补益中药复方的药理研究[J]中成药研究,1987(01).
  • 2傅桂云,王庆贵,吴忠帎.六味地黄汤的药理研究[J]中成药研究,1986(04).
  • 3后德辉,李玲,王秋娟,陈贵发.五种原小檗碱型化合物对实验性耐缺氧及心律失常的作用[J]南京药学院学报,1983(01).

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