摘要
六味地黄汤ｐｏ１ｇ／ｋｇ，ｑｄ ５ｄ显著对抗Ｌａｎｇｅｎｄｏｒｆｆ灌流大鼠心脏低灌－再灌注诱发的心律失常，使室颤发生率降低５０％，持续时间缩短７３％，且能明显抑制甲状腺素引起的心脏肥厚，并降低心脏对心律失常易损性的增加，使肥厚心脏低灌－再灌注诱发的室颤发生率由１００％降至１０％。六味地黄汤能明显抑制肥厚心脏遭受低灌－再灌注损伤引起的组织内ＳＯＤ的进一步降低及ＭＤＡ含量的进一步升高，提示六味地黄汤的抗心律失常及对肥厚心脏的保护作用均与其抗氧自由基作用有关。
iuwei Dihuang Decoction (LD) reduced arrhythmias induced by reperfusion in Langendorff's perfused rat heartspretreated at 1g/kg for 5d. In LD treated group, the incidence of ventricular fibrillation (VF) was reduced by 50%,and the duration of VF was shortened by 73%, LD exerted a beneficial effect on cardiomyopathy caused by l-thyrox-in, which was reflected in the attenuation of hypertrophy and vulnerability of hearts to arrhythmias, and the incidenceof VF in diseased hearts was reduced from 100% to 10% by LD preteatment. We also observed that LD significantlyinhibited the depletion of myocardial SOD in both normal and diseased hearts subjected to ischemia-reperfusion insult,which suggested that the antioxidation was contributed to the antiarrhythmia action of LD.
出处
《中药药理与临床》
CAS
CSCD
1995年第3期1-3,共3页
Pharmacology and Clinics of Chinese Materia Medica
