摘要
本文研究了肾上腺素能α－，β－１－受体和ＤＡ受体在促甲状腺素释放激素（ＴＲＨ）抗兔失血性休克中的重要性。结果显示β－１－受体拮抗剂美多心安（１ｍｇ／ｋｇ），ＤＡ受体拮抗剂氟哌啶醇（１ｍｇ／ｋｇ）单用或联合用药预处理可取消ＴＲＨ抗兔失血性休克的作用，而α－受体拮抗剂酚妥拉明（２ｍｇ／ｋｇ）预处理则不取消ＴＲＨ的抗休克作用，表明ＴＲＨ的抗休克作用与β－１－肾上腺素能受体和多巴胺受体密切相关，而与α－肾上腺素能受体关系不大。
The importanceof α,βand DA receptor in the protective effect of thy-rotropin releasing hormoneTRH)n hemorrhagic shock rabbits was investigated. The results showed that pretreatment with either βadrenoceptor antagonist metoprolol ( 1mg/kg)or DA receptor antagonist haloperidol( 1 mg/kg) or both could abolish the beneficial effects of TRH on the hemorrhagic shock,TRH could not improve the hemodynamic parameters after pretreatlnent with them, while pretreatment with α receptor antagonist phentolamine(2 mg/kg)had no significant influence on the protective effects of TRH. The results suggested that the protective effects of TRH on shock might be mediated by β-adrenoceptors and DA receptors but not by α-adrenceptors.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1995年第4期400-403,共4页
Chinese Journal of Pathophysiology
关键词
促甲状腺素
释放激素
休克
受体
肾上腺素能
Thyrotropin releasing hormone
Shock, hemorrhagic
Receptors,adrenergic
