摘要
本文观察促甲状腺素释放激素(TRH)对正常小鼠脾脏 T.B 细胞和免疫抑制小鼠免疫器官重量的影响.发现 TRH0.01～7.29nmol/L 剂量可提高小鼠脾细胞免疫特异性花结形成细胞数,而对产生抗羊红细胞抗体的功能无影响.0.0011～2.43nmol/LTRH对 ConA 诱导的 T 细胞转化有显著增强作用.TRH(0.2μg/只)能显著提高氢化可的松抑制小鼠的脾指数,而对正常小鼠脾指数影响不明显.提示 TRH 免疫调节作用存在明显的剂量效应关系,并与机体的免疫状态有关.
The influence of TRH on function of spleen T,B lymphocytes in normal mice and on immune organ weight in immunodepressive mice was studied.It was found that TRH at concentra- tions from 0.01 to 7.29nmol / L could increase S-RFC of mouse splenic cell in vitro,But not QHS. TRH at concentrations ranging from 0.0011to 2.43 nmol/L could significantly enhance ~3H-TdR uptake of T lymphocyte induced by ConA.The dose of TRH(0.2ug/mouse) i.p could significantly increase splenic index which was inhibited by HC.The results suggest that TRH may have immunoregulation.
出处
《皖南医学院学报》
CAS
1992年第1期5-7,共3页
Journal of Wannan Medical College
关键词
免疫功能
促甲状腺素
释放激素
Thyrotropin reseasing hormone
T-lymphocytes
Spleen
B-lymphocytes
Thymus gland
