摘要
目的探讨HBsAg阳性、HBeAb阳性、HBcAb阳性(即所谓的小三阳)乙型肝炎患者病毒DNA含量变化与其ALT的相互关系。方法选择468例小三阳患者,同时进行血清乙肝五项、HBV-DNA、ALT的检测。采用电化学发光法检测乙肝五项,采用FQ-PCR法检测HBV-DNA,采用酶法检测ALT。结果 HBV-DNA含量在106、107以上的患者,其血清ALT含量异常增高的比例高于HBV-DNA含量在103及103以下的患者,二者差异有显著统计学意义(χ2=76.8,P<0.05)。结论小三阳患者HBV-DNA含量越高,其体内血清ALT含量就越高,肝脏损伤程度越严重,HBV-DNA与ALT同时测定更明确地反映了患者体内病毒的感染情况。
Objective To explore the correlation of the changes in the level of HBV-DNA and ALT in patients with HBsAg＋,HBeAb＋and HBcAb＋.Methods 468 HBV cases with HbsAg＋,HbeAb＋,HbcAb＋ were chosen as the research objects.HbsAg,HbsAb,HbeAg,HbeAb and HbcAb were tested by electrochemiluminescence.HBV-DNA and ALT were detected by FQ PCR and enzyme immunoassays respectively.Results The serum ALT levels were higher when HBV-DNA content was above 106 or 107than when HBV-DNA content was below 103 or 103（χ2=76.8,P〈 0.05）.Conclusion The higher the level of HBV-DNA,the higher the level of serum ALT.Combined determination of HBV DNA and ALT can help to reveal virus infections.
作者
张霞
王桂凤
ZHANG Xia WANG Gui- feng(Qingdao No. 6 People＇s Hospital, Qingdao, China 26603)
出处
《山东医学高等专科学校学报》
2017年第2期118-121,共4页
Journal of Shandong Medical College
