摘要
目的：探讨乙肝病毒基因组（HBV-DNA）病毒载量与乙型肝炎血清标志物乙肝病毒e抗原（HBeAg）之间的关系。方法：对2007年1月~2010年1月同时采用时间分辨荧光分析仪和荧光定量聚合酶链反应（PCR）技术对440例各型乙型肝炎患者进行HBV-DNA含量及HBeAg定量结果进行回顾性分析。结果：血清学检测乙肝表面抗原（HBsAg）＋HBeAg患者HBeAg定量结果显著大于HB-sAg＋HBeAg＋乙肝病毒核心抗体（抗HBc）阳性（大三阳）患者（P〈0.05）。HBsAg＋HBeAg患者HBV-DNA定量结果波动范围也大于HB-sAg＋HBeAg＋抗HBc阳性患者。结论：HBeAg定量结果对病情的进展和诊治有一定的应用价值,HBeAg定量检查能较好地反映乙肝患者体内HBV-DNA的含量,揭示患者传染性强弱。
Objective：To investigate the relationship between hepatitis B virus genome（HBV-DNA） viral load with serological markers of hepatitis B virus,hepatitis B e antigen（HBeAg）.Methods：From January 2007 to January 2010,the time-resolved fluorescence analyzer and fluorescence quantitative polymerase chain reaction（PCR） technique were simultaneously adopted to detect the levels of HBV-DNA and HBeAg in 440 cases of various types of hepatitis B.The detection results were retrospectively analyzed.Results：The quantitative detection results of HBeAg in the patients with hepatitis B surface antigen（HBsAg） ＋ HBeAg were significantly greater than those in the patients with HBsAg ＋ HBeAg ＋ hepatitis B virus core antibody（anti-HBc） positive（P0.05）.The fluctuation range of quantitative results of HBV-DNA in the patients with HBsAg ＋ HBeAg was greater than that in the patients with HBsAg ＋ HBeAg ＋ anti-HBc positive.Conclusion：HBV-DNA and HBeAg obvious positive correlation.HBeAg quantitative results have some application value to the progress of disease,diagnosis and treatment.HBeAg quantitative examination can reflect the content of HBV-DNA in vivo in hepatitis B patients and reveal the infectious strength.
出处
《现代医药卫生》
2011年第3期338-339,共2页
Journal of Modern Medicine & Health
