摘要
肝细胞恶性转化和癌变过程中,胰岛素样生长因子-I受体(IGF-IR)异常活化。IGF-IR过表达既可作为肝癌早期诊断的标志,又可作为肝癌靶向治疗的新靶点,且具有应用前景。本文对IGF-IR信号通路异常激活及分子靶向治疗肝癌等的研究进展作了综述。
Abnormal activation of the insulin- like growth factor- I receptor （IGF- IR） occurs during malignant transformation of hepatocytes and during hepatocarcinogenesis. IGF - IR overexpression has been proposed as a diagnostic biomarker for early - stage hepatocellular carcinoma （ HCC ） as well as a novel target for HCC therapy. This review summarizes the recent research of the IGF - IR signaling pathway abnormal activation in HCC and the results of molecular targeting studies.
出处
《临床肝胆病杂志》
CAS
2013年第6期473-476,共4页
Journal of Clinical Hepatology
基金
南通市社会事业科技创新计划(HS2012039)
江苏省临床医学科技专项(BL2012053)
关键词
肝肿瘤
受体
IGF
1型
抗体
单克隆
微RNAS
liver neoplasms
receptor, IGF type I
antibodies, monoclonal
microRNAs
