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胰岛素样生长因子-Ⅰ及其受体在胃癌的表达和意义 被引量：7

The expression and significance of IGF-Ⅰ and its receptor in human gastric cancer
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摘要 目的探讨胰岛素样生长因子Ⅰ(IGF-Ⅰ)及其受体(IGF-ⅠR)在胃癌的表达情况及临床意义。方法应用免疫组化方法检测40例原发性胃癌组织及其远端正常胃黏膜中IGF-Ⅰ和IGF-ⅠR的表达,并分析其表达与胃癌病理分级、临床分期、淋巴结转移、肿瘤侵袭深度的关系。结果胃癌组织IGF-Ⅰ和IGF-ⅠR表达的阳性率分别为80%、77.5%,均显著高于远端正常胃黏膜的阳性率27.5%、25%(P<0.005)。IGF-Ⅰ和IGF-ⅠR的表达与性别、年龄、分化程度无关(P>0.05);TNM分期Ⅲ+Ⅳ期胃癌组织的IGF-Ⅰ和IGF-ⅠR蛋白表达水平均高于Ⅰ+Ⅱ期(P<0.05);伴有淋巴结转移胃癌组织中的表达明显高于不伴有淋巴结转移者(P<0.05)。IGF-Ⅰ和IGF-ⅠR在胃癌组织中的蛋白表达水平呈正相关(rs=0.5824,P<0.001)。结论IGF-Ⅰ和IGF-ⅠR在胃癌组织中蛋白表达水平与胃癌TNM分期、转移能力有关,提示IGF-Ⅰ和IGF-ⅠR的高表达在胃癌的发展过程中起了重要作用。 Objective To explore the expression and significance of insulin-like growth factor-Ⅰ （IGF-Ⅰ） and （IGF- Ⅰ R） in human gastric cancer. Methods We analyzed the expression of IGF- Ⅰ and IGF- I R in 40 paired samples of tumor-free tissues and carcinomatous gastric tissues by immunohistochemistry. The relationship of expression of IGF- Ⅰ and IGF- Ⅰ R with various clinicopathological parameters were analyzed. Results As measured by immunohistochemistry, the positive rates of IGF- Ⅰ and IGF- Ⅰ R expressions in tumor tissues were 80% and 77.5%, significantly higher than that of 27.5% and 25% in tumor-free tissues, respectively （P 〈 0. 005）. No correlation were found between expression levels of IGF- Ⅰ/IGF- Ⅰ R and differentiation of patients sex, age, histology （P 〉 0.05 ）. The IGF- Ⅰ and IGF- ⅠR protein expressions were higher in stage Ⅲ＋ Ⅳ of gastric cancer than that in stage Ⅰ ＋Ⅱ of gastric cancer, and were higher in gastric cancer with lymphnode metastasis than that in those without lymphnode metastasis （P 〈 0.05）. There was a positive correlation between the overexpression of IGF- Ⅰ and IGF- Ⅰ R in the gastric cancer. Conclusion The over expression of IGF- Ⅰ/IGF- Ⅰ R in gastric cancer is correlated with the TNM stage and the metastasis. Our results suggest that IGF- Ⅰ/IGF- Ⅰ R plays an important role in the pathogenesis of gastric cancer.
作者 丁娟娟 王邦茂 方维丽 曹晓沧 章明放
机构地区 浙江省义乌市中医院内科 天津医科大学总医院消化科
出处 《胃肠病学和肝病学杂志》 CAS 2009年第2期103-105,共3页 Chinese Journal of Gastroenterology and Hepatology
关键词 胃癌 胰岛素样生长因子-Ⅰ 胰岛素样生长因子-Ⅰ受体 免疫组化 Gastric cancer Insulin-like growth factor- Ⅰ （ IGF- Ⅰ ） Insulin-like growth factor- Ⅰ receptor （IGF- Ⅰ R） Immunohistochemistry
分类号 R735.2 [医药卫生—肿瘤]
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参考文献8

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二级参考文献11

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胃肠病学和肝病学杂志
2009年 第2期

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