摘要
肝癌(hepatocellular carcinoma,HCC)是全球最常见的恶性肿瘤之一,其特征是生长快、预后极差.肝癌的治疗正面临挑战,其机制尚未明朗.近来已证实了肝癌的一些靶向分子,正用于肝癌治疗的研究中.肝癌进展与肝中生长因子的过表达密切相关,且这些生长因子可能是肝癌治疗的分子靶目标.本文总结了肝细胞癌变过程中几种相关生长因子(IGF-Ⅱ、VEGF、TGF-β1和HGF)的动态表达与变化.
Hepatocellular carcinoma （HCC） is a common hepatic malignancy worldwide. Its nature of rapid growth results in a grave prognosis. Its treatment is challenging because the mechanisms underlying tumor progression are still largely unknown. Recently, new molecular targets have been confirmed and various targeted agents are now being investigated for the treatment of HCC. The progression of HCC is closely associated with growth factors that may for HCC treatment. This expression of hepatic be molecular targets paper concludes the expression characters and dynamic changes of several hepatoma-related growth factors such as IGF- Ⅱ, VEGF, TGF-β1 and HGF.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第23期2570-2575,共6页
World Chinese Journal of Digestology
关键词
肝癌
胰岛素样生长因子-Ⅱ
血管内皮生长因子
转化生长因子Β1
肝细胞生长因子
Hepatocellular carcinoma
Insulin-like growth factor-Ⅱ
Vascular endothelial growth factor
Transforming growth factor-β1
Hepatocytegrowth factor
