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喉鳞状细胞癌组织中胰岛素样生长因子-Ⅰ与胰岛素样生长因子-Ⅰ受体蛋白的表达 被引量：3

Expression of IGF-Ⅰ and IGF-ⅠR in larynx squamous carcinoma tissue
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摘要 目的:探讨胰岛素样生长因子-Ⅰ(IGF-Ⅰ)及其受体(IGF-ⅠR)在喉鳞状细胞癌发病机制中的作用。方法:采用免疫组织化学方法检测57例喉鳞状细胞癌组织和16例正常喉黏膜组织中IGF-Ⅰ与IGF-ⅠR的表达,并与临床病理资料结合进行统计学分析。结果:喉鳞状细胞癌组织中IGF-Ⅰ及IGF-ⅠR的阳性表达率(70.18%和75.44%)明显高于正常喉黏膜上皮组织(37.50%和25.00%,P<0.05);喉鳞癌组织中IGF-Ⅰ和IGF-ⅠR的表达与淋巴结转移及临床分期有关(P<0.05);喉鳞癌组织中IGF-Ⅰ与IGF-ⅠR的表达呈正相关。结论:IGF-Ⅰ及IGF-ⅠR的高表达与喉鳞癌的发生发展及浸润转移密切相关。 Aim ： To study the roles of insulin-like growth factor- Ⅰ （ IGF- Ⅰ ） and insulin-like growth factor- Ⅰ receptor （IGF- Ⅰ R） in the carcinogenesis of larynx squamous carcinoma （LSC）. Methods：The expressions of IGF- Ⅰ and IGF- Ⅰ R were detected by immunohistochemical staining in 57 cases of LSC tissue and 16 cases of normal laryngeal epithelium tissue. Results： The expression levels of IGF- Ⅰ and IGF- Ⅰ R in LSC tissue （70.18% and 75.44% ） were higher than those in normal laryngeal epithelium tissue（37.50% and 25.00% , P 〈 0.05 ）. The expression of IGF- Ⅰ and IGF- Ⅰ R in LSC tissue were related with lymph node metastasis and clinical stage（P 〈 0.05）. The expression of IGF- Ⅰ and IGF- Ⅰ R were positively correlated in LSC tissue. Conclusion：The higher IGF- Ⅰ and IGF- Ⅰ R expression is correlated with genesis,invasion and metastasis of LSC.
作者 赵玉林 王明婧
机构地区 郑州大学第一附属医院耳鼻咽喉头颈外科 海南省农垦总局医院耳鼻喉科
出处 《郑州大学学报（医学版）》 CAS 北大核心 2009年第1期87-90,共4页 Journal of Zhengzhou University(Medical Sciences)
基金 河南省医学高新技术发展扶持项目20060011 河南省教育厅自然科学基金资助项目2007320076
关键词 喉肿瘤 鳞状细胞癌 胰岛素样生长因子-Ⅰ 胰岛素样生长因子-Ⅰ受体 laryngeal neoplasm squamous carcinoma IGF- Ⅰ IGF- Ⅰ R
分类号 R739.6 [医药卫生—肿瘤]
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参考文献8

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共引文献31

同被引文献55

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郑州大学学报（医学版）
2009年 第1期

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