摘要
目的 :进一步认识利培酮与氯氮平治疗精神分裂症的疗效和副作用差异。 方法 :收集在国内精神科杂志上公开发表的 9篇关于利培酮与氯氮平对照治疗精神分裂症研究的文章 ,并作 Meta分析。 结果 :利培酮治疗前后自身对照比较 :综合检验 Z1 =40 .86 ,P<0 .0 1,提示利培酮治疗精神分裂症前后症状学变化有非常显著性差异 ,d1 =3.1,表明这种治疗效应极大。与氯氮平对照组的组间比较 :Z2 =- 4.41,P>0 .0 5 ,提示两种药物的疗效没有显著性差异 ,d2 =0 .49,表明这种差异效应偏小。利培酮组肌强直、震颤显著多于氯氮平组 ,差异有显著性 (χ2 =16 .74,P<0 .0 1,χ2 =17.2 3,P<0 .0 1) ,且这种差异的强度偏大 (d=0 .6 ,d=0 .5 3) ,其发生的比值比分别为 2 8.4和 12 .6 ;其他副作用显著少于氯氮平组 ,差异有显著性 (χ2 =5 .2 9～ 95 .72 ,P<0 .0 1) ,且强度较为明显 (d=0 .2～ 1.5 1) ,其发行的比值比在 1.9～ 33.6之间。 结论 :虽然利培酮与氯氮平在平均 8周左右的疗效无差异 。
Objective:To study the differences in therapeutic effects and side effects between risperidone (Ris) and clozapine (Clo). Method:Meta analysis was made for 9 papers published about comparative study of Ris and Clo. Results:The significant difference in pre and post treatment of Ris group was found(Z=40 86, P <0 01), and its therapeutic effect size was 3 1(=3 1), indicating therapeutic effect was great.No difference was found between group Ris and group Clo after treatment (Z=-4 41, P >0 05), and difference efficacy was not significant (=0 49). The incidence of muscular rigidity and tremor in group Ris were significantly different from group Clo(χ 2=16 74, P <0 01;χ 2=17 23, P <0 01), and its effect size was very great (d=0 6,d=0 53), their odd ratio (OR) was 28 4 and 12 6 respectively. The other side effects were lower in group Ris than that in group Clo (χ 2=5 29～95 72, P <0 01). The effect size of other side effect in group Clo was 0 2～1 51 with high level. Conclusion:Risperidone difference from clozapine is in side effects,but not in therapeutic effects.
出处
《临床精神医学杂志》
2000年第4期202-204,共3页
Journal of Clinical Psychiatry
