摘要
目的 :进一步探讨氟西汀与氯丙咪嗪治疗强迫症的疗效和副作用差异。方法 :收集 9篇主要在国内精神科杂志上公开发表的关于氟西汀与氯丙咪嗪对照研究的文章 ,取其研究结果作Meta分析。结果 :氟西汀治疗前后自身对照比较 :综合检验Z1 =2 9.16 ,P <0 .0 1,提示氟西汀治疗强迫症前后症状学变化差异有非常显著性 ;d1 =3.19,表明这种治疗效应极大。与氯丙咪嗪对照组组间比较 :Z2 =1 47,P >0 .0 5 ,提示两种药物的疗效差异无显著性 ;d2 =0 .2 8,表明这种差异效应极小。治疗后副作用 ,综合检验Z =- 2 3.42 ,P <0 .0 1,提示氟西汀的副作用显著少于氯丙咪嗪 ;d3=2 .6 6 ,表明两者差异效应极大。氟西汀组失眠、恶心呕吐、食欲下降多于氯丙咪嗪组 ,差异有显著性 (χ2 =9.12 ,P <0 .0 1;χ2 =2 4 5 2 ,P <0 .0 1;χ2 =1.93,P <0 .0 1) ,强度介于轻与重度之间 (d =0 .2 1～ 0 .914) ,其发生的比值比分别为3 93、10 8、1 13。其他副作用氟西汀组显著低于氯丙咪嗪组 (χ2 =0 .0 3～ 46 .2 0 ,P <0 .0 1) ,强度较为明显 (d =0 .41～ 1.45 ) ,其发生的比值比在 1 11～ 2 7 77之间。结论 :氟西汀与氯丙咪嗪在 6～ 10周的疗效无差异 。
Objectives:To study the difference of therapeutic effects and side effects between Flu and Clo.Methods:Meta analysis was from 9 published papers on comparative study of Flu and Clo.Results:The significant difference between pre and post treatment of Flu group was found(Z 1=29.16, P <0.01),and it's therapeutic effect size was 3.19(d 1=3.19).The incidences of insomnia,vomiting and nausea in group Flu were significantly different from Group Clo( χ=1.93-24.52,p<0.01) and it's effect size was between middle and great.The other side effects were lower in group Flu than that in group Clo( χ 2=1.93-24.52,p<0.01 )and it's effect size was between middle and great.The other side effects were lower in group Flu than that in group Clo( χ 2=0.03-46.20,p<0.01 ).The effect size of other side effect in group Clo was 1.11-27.77 with high level.Conclusion:Fluoxetine had significant difference from Clo on side effects but was equal in therapeutic effects.
出处
《中国民政医学杂志》
2001年第4期241-244,共4页
Medical Journal of Chinese Civil Administration
关键词
氟西汀
氯丙咪嗪
强迫症
META分析
Fluoxetne Clopmipramine Obsessive compulsive disorder Meta analysis
