摘要
目的 :进一步认识氟西汀与氯米帕明治疗强迫症的疗效和不良反应差异。方法 :收集国内公开发表的 9篇关于氟西汀与氯米帕明治疗强迫症对照研究的论文 ,并作 Meta分析。结果 :氟西汀自身对照比较 ,综合检验 Z1 =2 9.6 4,P <0 .0 1,提示氟西汀治疗强迫症前后症状学变化有非常显著性差异 ,d1 =5 .37,表明这种治疗效应极大。与氯米帕明的组间比较 :Z2 =1.2 0 ,P >0 .0 5 ,提示两种药物的疗效没有显著性差异 ,d2 =0 .2 5 ,表明这种差异效应偏小 ,氟西汀组的失眠和恶心显著多于氯米帕明组 ,差异有显著性 (χ2 =14.5 8,P <0 .0 1;χ2 =12 .2 3,P <0 .0 1) ,且这种差异的强度偏大 (d=0 .89,d=0 .79) ,其发生的比值比分别为 6 .41和 4.2 6 ;其它不良反应显著少于氯米帕明组 ,差异有显著性 (χ2 =18.10～ 73,13,P <0 .0 1)且强度较明显 (d=1.0 1～ 3.73) ,其发生的比值比在 6 .91～ 2 9.86之间。结论 :氟西汀与氯米帕明在平均 8周左右的疗效无显著性差异 。
Objective: To study the differences of fluoxetine(Flu) and clomipramine(Clo) in therapeutic effects and side effects. Methods: Meta-analysis was carried for 9 published papers on comparative study of Flu and Clo. Results: The significant difference of Flu group in pre-and post-treatment was found (Z1=29.64, p<0 01), and its therapeutic effect size was (d1=5.73), indicating the therapeutic effect was great. No difference was found between group Flu and Clo after treatment (Z2=1.20, P<0.05), and difference efficacy was not significant (d2=0.25). The incidence of insomnia and nauseation in group Flu were significantly different from group Clo (x2=14.58,P<0.01; x2=12.32,P<0.01), and its effect size was very great (d=0.86,d=0.790), their odd ratio (OR) were 6.41 and 4.26, respectively. The other side effects were lower in group Flu than that in group Clo (x2=18.10～73.13,P<0.01).The effect size of other side effects in group Clo were 1.01～3.73 with high level. Conclusions: There are differences between Flu and Clo in side effects, but not in therapeutic effects.
出处
《天津药学》
2001年第3期24-26,共3页
Tianjin Pharmacy
关键词
氟西汀
氯米帕明
强迫症
fluoxetine, clomipramine, obsessive compulsive disorder, Meta-analysis
