摘要
在肝脏组织癌变过程中，雄激素及其受体可能起到重要作用。相关研究证实大多数肝细胞癌患者癌组织中都能检测到雄激素受体的表达，且雄激素受体的表达上调与肿瘤患者预后相关。最近研究表明雄激素受体通过各种途径参与肝细胞癌发生发展过程，以雄激素受体作为治疗靶点可能是肝细胞癌治疗的一种新疗法。
Androgen receptors appear to play a significant role in the hepatocarcinogenesis. Androgen receptors are found to be expressed in liver tumor, and the overexpression of androgen receptor is associated with poor prognosis. Recent researches have indicated that androgen receptors regulate various cellular events in liver carcinogenesis through various ways, and androgen receptor could be a potential cancer therapeutic target in hepatoeellular carcinoma.
出处
《国际肿瘤学杂志》
CAS
2012年第8期609-612,共4页
Journal of International Oncology
关键词
癌
肝细胞
受体
雄激素
基因表达调控
肿瘤
Carcinoma, hepatocellular
Receptors, androgen
Gene expression regulation, neoplastic
