摘要
目的探讨抗雄激素治疗肝癌（ＨＣＣ）的效果。方法利用建立的人肝癌的裸小鼠模型，动态测量癌瘤及癌周组织的雄激素受体（ＡＲ）变化，然后使用不同剂量氟硝丁酰胺治疗异位移植的人肝癌（Ｆ１、Ｆ２组），与生理盐水组（Ｃ组）、抗癌药物治疗组（Ｍ组）作效果比较。结果肿瘤及癌周组织胞核、胞浆的受体，随肿瘤的增大呈递减变化。Ｆ１组、Ｆ２组肿瘤受体明显减少，但肿瘤重量与Ｃ组比无明显差别（１４±０８ｇ，２７±１４ｇ，１７±０８ｇ），均比Ｍ组重。结论雄激素可能在肿瘤发生的启动阶段起作用；当肿瘤生成后再使用抗雄激素治疗可能是无效的。
Objective To investigate the effect of antiandrogen on hepatocellular carcinoma(HCC). Methods Nude mice model with orthotopic transplanted human HCC was constructed and the androgen receptor(AR) in tumor and surrounding liver tissue was assayed dynamically. Nude mice with ectopic transplanted HCC were treated with flutamide (blocker of AR) at two different dosages (Group F1, F2), normal saline(Group C), and anticancer drug(Group M). The effect of treatments was compared among the groups. Results The quantity of AR in nucleus and cytoplasm in tumor and tumor surrounding tissue decreased with the increasing size of tumor in proper order. AR in tumor was significantly less in F1 and F2 groups than in other groups. The tumor weight of group F1,F2 and C had no significant difference (1 36±0.82g, 2 66±1.40g, 1 66±0 79g, respectively), but was significantly higher than that of group M. Conclusion Androgen may play a role at the initial stage of hepatocarcinogenesis, and antiandrogen therapy may be ineffective in the established tumor.
出处
《中华医学杂志》
CAS
CSCD
北大核心
1998年第4期299-300,共2页
National Medical Journal of China
基金
广东省科委自然科学基金
