摘要
目的分析血清超敏C反应蛋白（hs．CRP）、脂蛋白（a）[Lp（a）]、总胆固醇（TC）与高密度脂蛋白胆固醇（HDL-C）比值在冠心病检测中的临床意义。方法2010年9月至2011年9月，分别检测176例冠心病患者（冠心病组，其中急性心肌梗死56例，稳定型心绞痛58例，不稳定型心绞痛62例）以及60例健康对照者（对照组）血清hs-CRP、Lp（a）水平和TC／HDL—C。结果冠心病组血清hs—CRP、Lp（a）和TC／HDL．C分别为（34．51±9．65）mg／L、（295．16±104．57）mg／L和4．23±0．91，而对照组分别为（1．26±0．69）mg／L、（145．26±42．19）mg／L和2．54±0．57，两组比较差异有统计学意义（P〈0．05）。急性心肌梗死患者血清hs—CRP、Lp（a）和TC／HDL．C明显高于不稳定型心绞痛患者和稳定型心绞痛患者（P〈0．05）；不稳定型心绞痛患者血清hs．CRP、Lp（a）和TC／HDL-C明显高于稳定型心绞痛患者（P〈0．05）。结论血清hs．CRP、Lp（a）和TC／HDL—C在冠心病患者中明显升高，可以反映冠心病的严重程度。
Objective To analyze the significance of serum hyper sensitivity C-reactive protein （hs-CRP）, lipoprotein （a） [ Lp （ a ） ] and total cholesterol （ TC ）/high density lipoprotein cholesterol （ HDL-C ） in coronary heart disease. Methods From September 2010 to September 2011, the levels of serum hs-CRP, Lp （a） and TC/HDL-C were detected in 176 patients of coronary heart disease （coronary heart disease group） and 60 healthy controls （control group）. Coronary heart disease group included acute myocardial infarction with 56 cases, stable angina with 58 cases and unstable angina with 62 cases. Results The levels of serum hs-CRP, Lp （a） and TC/HDL-C in coronary heart disease group were （34.51 ±9.65 ） mg/L, （295.16± 104.57） mg/L and 4.23 ±0.91, while those in control group were （1.26 ±0.69） mg/L, （145.26 ±42.19） mg/L and 2.54 ± 0.57. There were significant differences between two groups （P 〈 0.05 ）. The levels of serum hs-CRP, Lp（a） and TC/HDL-C in acute myocardial infarction patients were significantly higher than those in unstable angina patients and stable angina patients（P 〈 0.05）. The levels of serum hs-CRP, Lp （a） and TC/HDL-C in unstable angina patients were significantly higher than those in stable angina patients （P 〈0.05）. Conclusions Serum hs-CRP, Lp （a） and TC/HDL-C are significantly increased in coronary heart disease, and can reflex the severity of coronary heart disease.
出处
《中国医师进修杂志》
2012年第10期15-17,共3页
Chinese Journal of Postgraduates of Medicine
