摘要
分析糖尿病患者颈动脉内膜中层厚度的改变 ,研究糖尿病与大血管病危险因素之间的关系。对 94例糖尿病患者和 6 1例非糖尿病患者行颈动脉超声检查 ,测定内膜中层厚度平均值、最大值及斑块厚度 ,并行血糖及血脂等检查。结果发现 ,糖尿病患者内膜中层厚度较非糖尿病患者明显增厚 (P <0 .0 5 ) ,斑块检出率显著增高 (P<0 .0 5 ) ,甘油三酯增高 ;非糖尿病伴高血压患者内膜中层厚度最大值增厚 (P <0 .0 0 1) ;血糖控制较好组内膜中层厚度较低 (P <0 .0 1) ,斑块检出率低 (P <0 .0 5 )。糖尿病组总胆固醇与高密度脂蛋白胆固醇比值与内膜中层厚度最大值呈正相关 (r=0 .32 ,P <0 .0 5 ) ,病程 <1年者总胆固醇与高密度脂蛋白胆固醇比值与内膜中层厚度最大值呈正相关 (r=0 .78,P <0 .0 5 ) ,且与糖化血红蛋白呈正相关 (r =0 .5 0 ,P <0 .0 5 )。结果提示 ,糖尿病、高血脂是大血管病的危险因素 。
Aim To examine carotid intima media thickness (IMT) and its determinants in elderly type 2 diabetes(DM)subjects, classified according to the new criteria of WHO 1999, in comparison with age and sex matched controled subjects with normal glucose level. Methods We compared the results of common carotid IMT and plaques from the subjects of type 2 diabetics aged 60～84 years with that of the non diabetic as controls. Results The diabetes subjects, both men and women, displayed carotid intima media thickness (P<0.05). Among the coronary risk factors, triglycerides (TG) was significantly increased and high density lipoprotein cholesterol (HDLC) decreased. In the diabetic group, IMT was correlated to triglycerides, TC/HDLC(P<0.05), HbA1c (P<0.05), blood pressure, age, sex, and duration. Conclusions The results suggest that hyperglycemia, together with a clustering of risk factors, and in particular dyslipidemia, may cause intima media thickness in the elderly type 2 diabetic patients.
出处
《中国动脉硬化杂志》
CAS
CSCD
2002年第2期149-151,共3页
Chinese Journal of Arteriosclerosis
关键词
糖尿病
内膜中层厚度
动脉粥样硬化
超声
Diabetes Mellitus
Intima Media Thickness
Atherosclerosis
Altrasound
