摘要
目的:探讨冻融胚胎移植周期中胚胎复苏时间对妊娠结局的影响。方法:回顾分析行冻胚移植(FET)的206对夫妇共248个周期,根据解冻时间的不同分为A组(对照组):排卵后2～3d或注射黄体酮3～4d后解冻,培养2h移植;B组(实验组):提前1d解冻,培养20h移植。比较各组间患者一般资料、复苏胚胎存活率、完整率、临床妊娠率、胚胎着床率和流产率。结果:A、B组间患者年龄、不孕年限、不孕原因、继发不孕所占比例、第3日冷冻胚胎比例、冷冻胚胎数、移植时内膜厚度、优胚数、胚胎复苏存活率、完整率、平均移植胚胎数均未见差异,而B组临床妊娠率和胚胎着床率显著高于A组(46.36%、25.29%vs30.88%、13.54%,P<0.05),组间流产率未见差异。过夜培养后有胚胎生长组临床妊娠率高于无生长组(49.47%vs26.67%,P>0.05)。结论:冻胚移植周期中提前解冻可以改善妊娠结局。
Objective：To investigate impact of thawing time on outcome of frozen-thawed embryo transfer（FET） cycles.Methods：A total of 248 frozen-thawed embryo transfer cycles were included in this study.Embryos were cryopreserved on day 2 or day 3 by slow freezing protocol and were thawed by rapid-thawed protocol.All FET cycles were divided into two groups,group A（control group）：thawed on day 2 or day 3 after ovalution or day 3 or day 4 after progesterone injected;group B：thawed 20 h ahead and cultured overnight.The survival rate,integrity rate,clinical pregnancy rate and implantation rate between the two groups were observed.Results：There were no clinical differences between the two groups,but clinical pregnancy rate and implantation rate in group B were significantly higher compared with group A（46.36%,25.29% vs 30.88%,13.54%,P〈0.05）.Moreover,clinical pregnancy rate with blastomere-growth group was higher too.Conclusion：Thawing ahead and culture overnight may be more consistent with the time of transfer and it may improve the outcome of FET cycles.
出处
《生殖与避孕》
CAS
CSCD
北大核心
2010年第7期490-493,共4页
Reproduction and Contraception
关键词
冻融胚胎移植
过夜培养
移植时机
frozen-thawed embryo transfer（FET）
culture overnight
time of transfer
