摘要
目的了解新型肝炎病毒－ＴＴＶ的致病性和在健康人群和肝病患者中的流行情况．方法收集１８０份健康体检患者血清和１５６份不同类型肝病患者血清，采用ＰＣＲ方法检测ＴＴＶ的ＤＮＡ．同时检测ＨＡＶ，ＨＢＶ，ＨＣＶ，ＨＥＶ和ＨＧＶ感染标志，比较分析ＴＴＶ在健康人群和不同类型肝病患者中流行情况及其致病性．结果健康体检人群和肝病患者中，ＴＴＶＤＮＡ检出率分别为２２％和４５％，两组间无显著性差异（Ｐ＞００５）．体检人群中，ＡＬＴ正常和升高者的检出率分别为１７％和１４３％．急性肝炎，慢性肝炎和肝硬变者的检出率分别为４８％，４３％和４７％．１１例阳性患者中，３例ＡＬＴ正常，８例ＡＬＴ异常．在８例ＡＬＴ异常患者中，６例为ＨＢＶ现行感染，１例为ＨＣＶ现行感染，仅１例为ＮＡ－Ｇ肝炎患者．结论在中国健康体检人群和肝病患者中能检出低水平的ＴＴＶ现行感染．但似乎仅引起个别患者的转氨酶轻度升高．ＴＴＶ的致病性可能较弱或需要其他因素协同致病．
AIM To investigate the incidence of TTV infection in normal population and patients with liver diseases, and analyze its pathogenesis. METHODS PCR was used in the detection of TTV DNA in 180 serum samples from routine medical check up persons and 156 serum samples from various types of liver diseases. Other hepatitis viruses were simultaneously detected using routine methods. Pathogenesis of TTV was analyzed by comparison of TTV infection between normal persons and patients with liver diseases. RESULTS TTV DNA was found in 2 2% and 4 5% in routine medical check up persons and liver disease patients respectively, with no significant difference ( P >0 05). The positive rates were 1 7% and 14 3% in normal persons and those with elevated ALT level respectively, and 4 8%, 4 3% and 4 7% in patients with acute hepatitis, chronic hepatitis and cirrhosis respectively. There were 6 cases of current HBV infection, 1 case with present HCV infection, only one patient had non A/G hepatitis among 8 positive cases with elevated ALT. CONCLUSION TTV infections are observed in Chinese populations of either normal persons or liver disease patients. The pathogenesis of TTV might be very weak or dependent on the interaction with other factors.
出处
《世界华人消化杂志》
CAS
1999年第1期5-7,共3页
World Chinese Journal of Digestology
基金
广东省病毒性肝炎防治专项基金
关键词
肝炎
肝炎病毒
DNA
病毒
TTV
hepatitis, viral
hepatitis, virus
DNA, viral/analysis
