摘要
目的研究老年慢性病毒性肝炎（ＣＶＨ）患者血清微量元素的变化。方法老年ＣＶＨ患者４７例，健康人４５例；非老年ＣＶＨ４５例，健康人４２例，测定其血清铜、锌、镉、锰、硒的含量，并对这些微量元素作两两直线相关分析。结果与非老年ＣＶＨ及健康人相比，老年ＣＶＨ患者血清铜（１１．８１±０．９４μｍｏｌ／Ｌ）、锌（９．３３±０．３１μｍｏｌ／Ｌ）、锰（０．３０±０．０３μｍｏｌ／Ｌ）、硒（０．５１±０．０７μｍｏｌ／Ｌ）含量明显减少（Ｐ＜０．０１），镉（７７．３４±６．７６ｎｍｏｌ／Ｌ）显著升高（Ｐ＜０．０１），血清锌、锰、硒之间两两呈正相关，与铜和镉为负相关（Ｐ＜０．０１）。
AIMS To study the changes of serum trace elements in senile patients with chronic viral hepatitis(CVH). METHODS Serum trace elements in 47 senile patients with CVH, 45 healthy senile persons, 45 non_senile patients with CVH and 42 healthy non_senile persons were studied. The serum levels of copper, zinc, cadmium, manganese and selenium were tested, and their linear correlations between each other were analysed. RESULTS The levels of serum copper (11.81±0.94μmol/L),zinc(9.33±0.31μmol/L),manganese (0.30±0.03μmol/L) and selenium(0.51±0.07μmol/L) were lower, than those in non_senile cases of CVH and healthy persons(P<0.01), and the serum cadmium(77.34±6.76nmol/L) was higher (P<0.01). Meanwhile the serum level of zinc, manganese and selenium had positive correlations each other (P<0.01), but had negative correlation(P<0.01) with serum copper and cadmiun in senile patients with CVH. CONCLUSIONS The serum level of trace elements for senile patients with CVH may be related to the senility and pathologic changes in the liver.
关键词
微量元素
病毒性肝炎
血清
老年人
trace elements/blood hepatitis, viral, human/blood aged liver metabolism
