摘要
目的研究血清层粘蛋白（ＬＮ）和透明质酸（ＨＡ）对慢性肝病的诊断意义。方法检测急慢性肝炎及肝硬变患者血清ＬＮ和ＨＡ浓度，与肝功能及食管静脉曲张程度和肝脏病理进行比较。结果慢性肝炎血清ＬＮ明显高于健康者和急性肝炎，肝硬变患者血清ＬＮ升高幅度较大，是慢性肝炎（ＣＨ）患者的１．８倍（Ｐ＜０．０１）。ＨＡ以４００μｇ／Ｌ为界，ＬＮ以１５０μｇ／Ｌ为界，肝硬变同时升高者占８５．２％。ＣＨ则为９．７％，两组比较差异非常明显（Ｐ＜０．０１）。慢性丙型肝炎患者早期血清ＬＮ就显著升高，电镜观察发现丙型肝炎患者贮脂细胞及成纤维细胞增多，此种病理现象较ＣＨ患者明显。
AIMS To study the clinical significance of serum laminin(LN) and hyaluronic acid(HA) in patients with chronic liver diseases. METHODS The concentrations of serum LN and HA in patients with acute (n=10) or chronic hepatitis (n=39) and cirrhosis (n=27) were detected by using IRA. The relation between LN, HA and liver function and pathology was analysed. RESULTS Serum LN in patients with chronic hepatitis(CH) and cirrhosis is much higher than those in patients with acute hepatitis and healthy people. Serum LN in patients with cirrhosis was 1.8 times as high as CH(P<0.01). If the levels of serum HA and LN were defined to 400 and 150μg/L respectively, serum HA and LN increase accounted for 85.2% in cirrhosis but 9.7% in CH. The difference is very obvious between two groups(P<0.01). Serum LN increased obviously in patients with early chronic hepatitis C. Liver FSC and fibrocytes were increased under electro_microscope. CONCLUSIONS The concentrations of serum LN and HA are useful in the differential diagnosis of liver cirrhosis and fibrosis.
关键词
透明质酸
层粘蛋白
肝疾病
血清
laminin /blood hyaluronic acid/blood hepatitis, viral, human/blood liver cirrhosis/blood
