摘要
目的:研究丹参类注射剂与不同品种的喹诺酮类注射剂配伍后的稳定性。方法:采用高效液相色谱法分别测定配伍后丹参类注射剂中丹参素钠、原儿茶醛、丹参酮ⅡA和各喹诺酮类药物的含量;用酸度计测定配伍液的pH值变化并观察配伍液性状变化。结果:配伍后,所有喹诺酮类药物输液均能反应产生浑浊;丹参素钠、原儿茶醛含量无变化,丹参酮ⅡA含量下降至几乎为0;喹诺酮类药物含量测得约为标示量的90%,略有下降;反应与pH值变化无关。结论:此两类注射剂不能混合在同一容器中,应用适宜的输液分隔,或分开时间段静脉滴注。
OBJECTIVE： To study the compatibility of Danshen Injections （in different dosage forms） and Quinolones Injections （in different varieties）. METHODS： The contents of tanshinol sodium, protocatechualdehyde and tanshinone ⅡA in Danshen Injections as well as the contents of different Quinolones after mixing Danshen Injections （in different dosage forms） with Quinolones Injections （in different varieties） were determined by HPLC. The pH values of the mixtures were detected by acidometer and the properties of the mixtures were observed. RESULTS： After mixing of two, turbid reactions were noted in all the infusions of Quinolones; the contents of tanshinol sodium and protocatechualdehyde in the mixture were stable, whereas the content of tanshinone ⅡA decreased to almost 0; and the contents of Quinolones decreased slightly, and which were measured at about 90% of the labeled amount. The infusion reactions were independent of the pH value. CONCLUSION： Danshen Injection can＇t be mixed with Quinolones Injection in the same container; instead, they should be placed with suitable infusion separation and infused singly in different time period.
出处
《中国药房》
CAS
CSCD
北大核心
2009年第26期2040-2042,共3页
China Pharmacy
关键词
注射用丹参
丹参注射液
丹参酮ⅡA
磺酸钠注射液
喹诺酮
配伍
Danshen for Injection
Danshen Injection
Tanshinone ⅡA Sulfotanshinone Sodium Injection
Quinotones
Compatibility
