摘要
目的：建立灵丹片的质量控制方法。方法：采用薄层色谱法对灵丹片中的丹参、川芎进行定性鉴别；并用可见-紫外分光光度法对其中灵芝多糖含量进行测定，用高效液相色谱法对制剂中丹参酮ⅡA的含量进行测定。结果：TLC鉴别方法专属性强；含量测定灵芝多糖、丹参酮ⅡA分别在5．34-32．1mg·L^-1，2．4～42．9mg·L^-1范围内线性关系良好，平均回收率分别为100．15％（RSD=1．05％）、99．74％（RSD=0．77％）。结论：所建立的定性、定量方法简便、灵敏、准确，可作为该制剂质量控制用。
OBJECTIVE To establish the quality standard for Lindan tabets. METHODS Radix Salviae miltiorrhizae and Rhizoma Chuanxiong were identified by TLC, The contents of polysaccharides in Lingzhi was detected by UV-spectrophometry, while HPLC was used to determine tanshinone Ⅱ A. RESULTS TLC identification was highly specific and the spots were clear. The linear range for polysaccharides in Lingzhi and tanshinone Ⅱ A were in the range of 5.35 - 32. 1 mg· L^- 1,2. 42 - 42. 9 mg·L^-1. Their average recovery were 100. 15% （RSD = 1.05%） and 99. 74%（RSD = 0. 776%）. CONCLUSION The method is simple,sensitive, accurate and can be used for quality control of Lindan tabets.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2006年第6期708-710,共3页
Chinese Journal of Hospital Pharmacy
关键词
灵丹片
质量标准
丹参酮Ⅱ
A
灵芝多糖
Lingdan tablets
quality ctandard
tanshinone ⅡA
polysaccharides in Lingzhi
