摘要
目的 :建立复方当归胶囊的质量控制方法。方法 :采用薄层色谱法对制剂中主要药材当归、丹参、黄芪、延胡索进行定性鉴别 ;采用高效液相色谱法对主药材当归中的阿魏酸、丹参中的丹参酮ⅡA 进行定量测定。结果 :薄层图谱斑点清晰 ,阴性对照无干扰 ;阿魏酸进样量在0 00255μg～0 0816μg 之间线性关系良好 (r=0 9997) ;丹参酮ⅡA 进样量在0 01μg～0 06μg 之间线性关系良好 (r=0 9995)。结论 :本方法简便 ,重现性好 ,可有效控制制剂质量。
OBJECTIVE:To establish the quality control method of angelica capsule.METHODS:The chief components of the preparation,radix angelica sinensis,radix salvia miltiorrhizae,rhizoma corydalis,radix astragali,which were identified by TLC;the content of ferulic acid in angelica and tanshinoneⅡ A in Salvia were determined by HPLC method.RESULTS:The TLC(thin layer chromatogram)spots were clear;the linearity of ferulic acid was within the range of0.00255μg～0.0816μg(r=0.9997)and the linearity of tanshinoneⅡ A was within the range of0.01μg～0.06μg(r=0.9995).CONCLUSION:Th_ is method is simple and highly reproductive,which can be used for the quality control of preparation.
出处
《中国药房》
CAS
CSCD
北大核心
2005年第5期352-354,共3页
China Pharmacy
关键词
复方当归胶囊
质量标准
阿魏酸
丹参酮ⅡA
Compound angelica capsule
Quality standard
Ferulic acid
TanshinoneⅡ_A
