摘要
目的：探讨心理干预对恶性肿瘤放疗患者情绪及免疫功能的影响。方法：将77例肿瘤放疗患者随机分为干预组38例与对照组39例，对照组给予放疗及常规对症治疗和护理，干预组则在放疗及常规对症治疗护理的基础上给予心理干预。分别于放疗前后采用症状自评量表（SCL-90）进行情绪测试，随机选择两组肿瘤放疗患者各15例分别于放疗前后检测T细胞亚群CD3^＋，CD4^＋，CD8^＋，CD4^＋／CD8^＋和NK细胞，并分析心理干预对肿瘤放疗患者情绪、应对方式及免疫功能的影响。结果：恶性肿瘤干预组患者放疗后SCL-90总分、总均分、阳性项目数、阳性症状均分、各因子分均明显低于放疗前和对照组（P〈0．05—0．001）；对照组患者放疗后SCL-90总分、总均分、阳性项目数、阳性症状均分、抑郁及焦虑因子分均显著高于放疗前（P〈0．05～0．001）。放疗后干预组的CD4^＋、NK细胞均明显高于对照组（P均〈0．05）；干预组放疗后NK细胞明显高于放疗前（P〈0．01）。结论：心理干预不仅可以改善肿瘤放疗患者的情绪状况，而且能提高机体免疫功能。
Objective ： To study the effect of psychological intervention on the mood and immune function in cancer patients receiving radiotherapy. Methods ： 77 cancer patients receiving radiotherapy were randomly divided into intervention group （ n = 38）and control group （ n = 39 ）. The radiotherapy and routine treatment and nursing care were used in both groups, while psycho- logical intervention was additionally applied in the intervention group. The patients were tested with Symptom Checklist 90 （ SCL -90） before and after radiotherapy. 15 patients were randomly selected from each group and T -lymphocyte subsets CD3^＋ CD^＋, CD8 ^＋, CD4^＋/ CD8^＋ and NK ceils were detected before and after radiotherapy, analyzing the effect of psychological intervention on patients mood, coping style and immune function. Results ： The total score of SCL - 90, the average score, the positive items, the positive symptoms and the factor scores were significantly lower in intervention group than that in control group and were lower after radiotherapy than that before radiotherapy （P 〈0.05 -0.001） ; the total score of SCL- 90, the average score, the positive items, the positive symptoms, the depression and anxiety factor scores were higher after radiotherapy than that before radiotherapy in control group （P 〈 0.05 - 0.001） ; CD4^＋ , NK cells were significantly higher in intervention group than that in control group after radiotherapy （ P 〈 0.05） ; NK cells were higher after radiotherapy than that before radiotherapy in intervention group （ P 〈 0.01 ）. Conclusion ： The psychological intervention can not only improve the mood of cancer patients receiving radiotherapy, but also enhance immune function.
出处
《齐鲁护理杂志》
2009年第6期4-6,共3页
Journal of Qilu Nursing
关键词
肿瘤
放疗
应对方式
免疫功能
心理干预
Tumor
Radiotherapy
Coping style
Immune function
Psychological intervention
