摘要
目的研究喉癌病人外周血Ｔ淋巴细胞亚群的分布状况及其意义。方法测定喉癌病人的外周血Ｔ淋巴细胞亚群的分布，并进行了连续观察研究。结果喉癌Ⅰ－Ⅲ期较Ⅳ期外周血Ｔ淋巴细胞亚群ＣＤ３、ＣＤ４、ＣＤ８和ＣＤ４／ＣＤ８均有显著性差异（Ｐ＜０．０５）。声门上型与声门型外周血Ｔ淋巴细胞亚群无显著性差异（Ｐ＜０．０５）。鳞状细胞癌Ⅰ－Ⅱ级较Ⅲ－Ⅳ级外周血Ｔ淋巴细胞亚群有显著性差异（Ｐ＜０．０５）。病人术后半个月外周血ＣＤ８较术前显著下降（Ｐ＜０．０５）、而ＣＤ３、ＣＤ４、ＣＤ４／ＣＤ８均无显著性差异（Ｐ＜０．０５）；术后三个月、术后半年、术后二年较术前外周血Ｔ淋巴细胞亚群ＣＤ８、ＣＤ４／ＣＤ８有显著性差异（Ｐ＜０．０５），ＣＤ３、ＣＤ４无显著性差异（Ｐ＞０．０５）。本组术后复发、转移或带癌生存的病人不同时期外周血Ｔ淋巴细胞亚群无显著性差异（Ｐ＞０．０５）。术后一年时，无癌生存者与复发、转移或带癌生存者，外周血Ｔ淋巴细胞亚群均有显著性差异（Ｐ＜０．０５）。结论连续测定喉癌病人外周血Ｔ淋巴细胞亚群，对了解病人的免疫状态，监视复发和预后有较大的临床意义。
Objective To study on the condition state of Peripheral blood T lymphocyte subjects in patients with larynx carcinoma.Methods Determined by monoclonal antibodies the condition state of peripheral blood T lymphocyte subjects in patients with larynx carcinoma,and study the condition state continuously.Results For the patients of larynx carcinoma,the percentage of CD3、CD4 and the ratio CD4/CD8 with the stage 4 disease were statistically significant decreased to the stage 1-3 disease.but the CD8 was statistically significant increased ( P<0.05 ).The percentage of CD3、CD4、CD8 and the ratio CD4/CD8 of the superaglottic cancer were no significant difference to the glottic cancer (p< 0.05 ).The percentage of CD3、CD4 and the ratio CD4/CD8 of larynx Squamous cell carcinoma with degree 3-4 were statistically significant decreased to the degree 1-2,but the percentage of CD8 was significant increased (P<0.05).For the patients of larynx carcinoma,the percentage of CD8 on half a month after operation was significant decreased to the pre operation ( P<0.05 ),but CD3、CD4 and the ratio CD4/CD8 were no significant difference ( P>0.05 ),on three months,half a year,one year and two years after operation,the percentage of CD8 was significant decreased to the pre operation( P<0.05 ),the ratio CD4/CD8 was significant increased (P<0.05),but the percentage of CD3、CD4 were no significant difference (P>0.05).The percentage of CD3、CD4、CD8 and the ratio CD4/CD8 of the patients with recurrence,metastsis and alive with disease were no signifcant difference before and during two years after operation ( P>0.05 ). On one year after operation,the percentage of CD3、CD4 and the ratio CD4/CD8 of the disease free were significant increased to the alive with disease ( P<0.05 ),but the CD8 was significant decreased ( P<0.05 ).Conclusion The above results indicate that determinmy peripheral blood T lymphocyte subsets have certain clinical significant in monitoring immune function,recurrence and prognosis of the patients with larynx carcinoma.
出处
《中国肿瘤临床与康复》
1999年第1期8-10,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
