摘要
目的探讨全胃切除术后患者早期、短期联合应用免疫增强型肠内营养（IEN）和重组人生长激素（rhGH）对疗效的影响。方法将48例胃恶性肿瘤患者双盲、随机分为单纯肠内营养组（EN组,16例）、IEN组（16例）和IEN加rhGH组（16例）。比较全胃切除术后3组患者的氮平衡、营养状况和免疫功能及疲倦度等指标。结果IEN加rhGH组在提高术后营养、免疫功能,纠正负氮平衡,改善疲倦度等方面较EN组和IEN组效果明显。术后第7天,IEN加rhGH组上述指标已恢复至正常水平;术后第10天,IEN加rhGH组氮平衡、血清蛋白[总蛋白（66.8±2.0）g/L比（65.8±0.9）g/L]、体液免疫、细胞免疫（除CD8外）[CD3（66.1±6.3）%比（60.5±5.6）%]和Christensen记分（4.6±0.9比6.3±0.9）差异有统计学意义（P〈0.05）。结论全胃切除术后早期、短期联用IEN和rhGH,对患者蛋白质合成及免疫功能恢复疗效显著。
Objective To explore the effect of immune-enhanced enteral nutrition （IEN） together with recombined human growth hormone （rhGH） on patients after total gastrectomy. Methods Forty-eight patients after total gastrectomy were randomly divided into EN group （n=16）, IEN group （n=16） and IEN＋ rhGH（n=16） group. Nitrogen balance, nutritional status, immune function and lassitude degree were compared among 3 groups. Results IEN＋rhGH group had better efficacy as compared to EN and IEN group in improving postoperative nutritional status, immune function, nitrogen balance and lassitude degree, and recoverd to normal level after 7 days. All the indexes of IEN＋rhGH group except CD8 were improved significantly on the 10th day after operation as compared to those of EN group[total protein（66.8±2.0）g/L vs （65.8±0.9）g/L, CD3（66.1±6.3）% vs （60.5±5.6）%, Christensen score （4.6±0.9） vs （6.3±0.9）, all P〈0.05]. Conclusion Early application of IEN combined with rhGH plays an effective role in improving protein metabolism and immune function for patients after total gastrectomy in short period.
出处
《中华胃肠外科杂志》
CAS
2007年第6期550-554,共5页
Chinese Journal of Gastrointestinal Surgery
关键词
胃肿瘤
胃切除术
肠内营养
人生长激素
免疫
Stomach neoplasms
Gastrectomy
Enteral nutrition
Human growth hormone
Immune
