摘要
目的:研究肠内免疫营养对胃癌手术后病人营养、免疫及炎症反应的影响. 方法:将96例胃癌病人随机分为肠内免疫营养组(研究组)和常规肠内营养组(对照组),分别于术后第2～8天给予等氮、等热量的肠内营养支持.于手术前1天、术后第1天和第9天分别检测总蛋白、清蛋白、前清蛋白、转铁蛋白、IgG、IgM、IgA、CD4、CD8、CD4/CD8、IL-1α、IL-2、IL-6、IL-10、TNF-α等项目,用药期间留24 h尿、粪测定氮,计算氮平衡. 结果:研究结束时研究组前清蛋白、IgA、CD4、CD4/CD8均显著高于对照组,IL-6、TNF-α显著低于对照组. 结论:肠内免疫营养可减轻胃癌病人手术创伤后机体炎症反应,改善免疫功能.
Objectives:To evaluate the role of early postoperative enteral immunonutrition on host nutritional status, immune and inflammatory responses. Methods:Ninety six patients with gastric cancer were randomized to receive either an immune enhancing enteral diet or an isocaloric, isonitrogenous control diet for 7 days. Enteral feeding was initiated 24 hours after surgery. Host immunity was evaluated by IgG、IgM、IgA、CD4、CD8、CD4/CD8, and inflammatory response was reflected by IL-1α、IL-2、IL-6、IL-10、TNF-α. Total protein, albumin, prealbumin,transferrin and nitrogen balance were determined as nutritional indicators. Results:After the study, prealbumin, IgA, CD4, and CD4/CD8 levels were significantly higher in study group than in control group. IL-6, TNF-α concentrations were significantly lower in study group than in control group. Conclusions:Postoperative administration of immunonutrition in patients with gastric cancer can positively modulate postoperative immunosuppressive and inflammatory responses.
出处
《肠外与肠内营养》
CAS
2005年第2期102-104,108,共4页
Parenteral & Enteral Nutrition
