摘要
目的探讨缺氧诱导因子1α(HIF-1α)在肺非小细胞肺癌(NSCLC)中的表达及与凋亡相关蛋白 Survivin、Bax 表达的关系。方法采用免疫组织化学方法检测52例 NSCLC 组织中 HIF-1α和 Survivin、Bax 的表达。结果 NSCLC 组织中 HIF-1α、Survivin、Bax 的阳性表达率分别为38.5%(20/52)、48.1%(25/52)和42.3%(22/52)。HIF-1α的表达与肿瘤临床分期(x^2=8.271,P<0.05)及淋巴结转移(x^2=6.370,P<0.05)相关,与肿瘤病理类型(x^2=0.561,P>0.05)及分化程度(x^2=0.326,P>0.05)无明显相关性。HIF-1α的表达与 Survivin 表达(γ=0.496,P<0.05)和 Bax 表达(γ=0.681,P<0.05)正相关。结论 HIF-1α表达与NSCLC 的浸润性发展、转移及凋亡发生密切相关。
Objective To investigate the expression of hypoxia inducible factor-1α （HIF-1α） and relationship thereof to survivin and Bax, apoptosis related proteins, in non-small cell lung cancer （NSCLC）. Methods Immunohistochemistry was used in 52 specimens of NSCLC to detect the expression of HIF-1α, survivin and Bax. Results The positive rates of HIF-1α,survivin and Bax were 38.5% （20/52）, 48.1% （25/52）, and 42.3% （22/52） respectively. The higher the pathological stage of tumor, the higher expression rate of HIF-1α （ X^2 = 8.271 ,P 〈0.05 ）. The positive rate of HIF-1α expression of the patients with lymph node metastasis was higher than that of the patients without lymph node metastasis （ X^2 = 6. 370,P 〈 0.05 ）. However, HIF-1α expression had no relationship to the pathological type （ X^2 = 0. 561, P 〉 0. 05 ） and differentiation degree （ X^2 = 0. 326, P 〉 0. 05 ）. Correlation analysis showed that the expression of HIF-1 ct was positively correlated with the surviving expression（ γ =0.496,P〈0.05） and Bax expression （γ =0.681,P 〈0.05）. Condusion The expression of HIF-1α is related to the infiltration, metastasis, and apoptosis of NSCLC.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2007年第13期921-923,共3页
National Medical Journal of China
关键词
缺氧诱导因子
免疫组织化学
癌
非小细胞肺
Hypoxia induce factor
Immunohistochemistry
Carcinoma, non-small-cell lung
