摘要
目的系统评价乏氧诱导因子-1α(HIF-1α)在非小细胞肺癌(NSCLC)中的表达水平及其与临床病理特征的关系。方法计算机检索Pubmed、EMBASE、Cochrane Library、中国期刊全文数据库、中国生物医学文献数据库和中文科技期刊全文数据库等,同时追查纳入文献的参考文献,纳入有关HIF-1α与NSCLC关系的临床研究。采用Stata 11.0软件进行统计学分析。结果共纳入19篇文献,1488例患者。Meta分析结果显示:(1)HIF-1α在NSCLC组中的阳性表达水平高于对照组(OR=35.55,95%CI:18.79～67.25,P=0.000)。(2)HIF-1α在NSCLC T3、T4期与T1、T2期的表达差异无统计学意义(OR=2.50,95%CI:0.89～6.97,P=0.081)。HIF-1α在NSCLC低分化与中、高分化(OR=1.81,95%CI:1.11～2.98),淋巴结转移与非淋巴结转移(OR=2.97,95%CI=1.84～4.80),临床分期Ⅲ、Ⅳ期与Ⅰ、Ⅱ期(OR=2.56,95%CI=1.58～4.15)的表达差异均有统计学意义(P<0.05)。结论 HIF-1α在NSCLC中呈高表达,并增加了NSCLC发生恶性行为的危险。
Objective To investigate the expression of hypoxia-inducible factor-1α（HIF-1α） in non-small cell lung cancer （NSCLC） and its relationship with clinicopathological feature with a systematic review. Methods Studies assessing clinical significance of HIF-1α expression in NSCLC published until April 2012 were selected on the basis of Pubmed, EMBASE, Cochrane Library, and CNKI. The meta analysis in this study was performed by the statistical software STATA 11.0. A meta analysis was performed to clarify the impact of HIF-1α expression on clinicopathological in NSCLC. Results A total of 19 studies were recruited. As ior the positive rate of HIF-1 ot expression, significant differences were tested between NSCLC and normal lung tissues（ OR = 35.55, 95% CI： 18.79-67. 25, P =0. 000）. There was no significant differences between T stages T3-T4 and T stages TI-T2 （ OR =2. 50,95% CI：0. 89- 6. 97 ,P = O. 081 ）. There were significant differences between low differentiation and medium- and high-differentiation （OR = 1.81, 95% CI：I. 11-2.98, P 〈0.05） , lymph node metastasis and non-lymph node metastasis（ OR =2. 97,95% CI ： 1.84-4. 80 ,P 〈0.05 ）, and clinic stages IlI-IV and clinic stages I -II （OR = 2. 56,95% CI：I. 58-4. 15 ,P 〈 0. 05 ）. Conclusion HIF-1α may play an important role in NSCLC, and the overexlaression of HIF-1α correlates with malignant biological behavior.
出处
《临床肿瘤学杂志》
CAS
2012年第10期894-898,共5页
Chinese Clinical Oncology
