摘要
目的分析T1G3膀胱移行细胞癌的复发特点。方法自北京协和医院1993至2003年的复发性膀胱移行细胞癌病例中,选择首次治疗方法相同的T1期病例72例,按病理分级分组,G3组37例,G1-2组35例。分别对首次复发时间,复发次数,复发肿瘤的数量、形态、病理分期以及复发后治疗方法等资料进行统计分析。结果T1G3组第1、2、3年及4年以上的复发率分别为29·7%、40·5%、18·9%及10·8%,T1G1-2组分别为14·3%、34·3%、31·4%及20·0%,两组比较差异有统计学意义(P=0·025)。T1G3组单次复发的4例(10·8%),3次以上复发的20例(54·0%),T1G1-2组分别为17例(48·6%)和6例(17·2%),两组比较差异有统计学意义(P<0·01)。T1G3组复发后肿瘤病理分期T2期以上的32例(86·5%),T1G1-2组15例(42·8%)。T1G3组最后一次复发后进行膀胱部分切除或膀胱全切治疗的35例(94·6%),T1G1-2组20例(57·1%),两组比较差异有统计学意义(P<0·01)。结论T1G3膀胱移行细胞癌治疗后近期易复发,且复发次数多,复发后多数发展为浸润癌,应当引起临床治疗上的重视,注意术后随访。
Objective To investigate the characteristics of recurrence of T1G3 transitional cell carcinoma （TCC） of bladder. Methods The clinical data of 72 patients with TCC of bladder of the stage T1, 37 being of the stage T1 G3 and 35 being of the stage T1 G1-2, who underwent the initial treatment by transurethral resection of bladder tumor plus post-operative bladder infusion were analyzed. Results The first, second, third, and fourth year recurrent rates of the T1 G3 group were 29.7% , 40.5% , 18.9% , and 10.8% respectively, all significantly higher than those of the T1G2 group （14.3% , 34.3% , 31.4%, and 20.0% respectively, t = 1. 994, P =0.025 ）. The rate of recurrence for only time was 10.8% in the TI G3 group （4/37）, significantly lower than that of the T1G1-2 group （ 17/35, 48.6% , P 〈0.01 ）. The rate of recurrence for more than 3 times was 54.0% in the T1 G3 group （ 20/37 ）, significantly higher than that of the T1G1-2 group （6/35, 17.2% , P〈0.01 ）. The rate of recurrent tumor at the pathological stage over T2 was 86.5% （32/37） in the T1G3 group, higher than that of the T1G1-2 group （42.8% , 15/35）. The rate of partial or total cystectomy at the last recurrence in the T1G3 group was 94.6% （35/37）, significantly higher than that of the TI G1-2 group （57.1%, 20/35, X2 = 14.00, P〈0.05 ）. Conclusion A kind of dangerous bladder cancer, TCC at the stage T1G3 is apt recur soon after the treatment with a high recurrent frequency. Most recurrent tumors evolve into invasive cancer.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2006年第19期1305-1308,共4页
National Medical Journal of China
关键词
膀胱肿瘤
癌
移行细胞
复发
Bladder neoplasms
Carcinoma
Transitional cell
Recurrence
