摘要
目的:探讨血管外皮细胞瘤的细胞增殖活性与肿瘤预后的关系。方法:35例血管外皮细胞瘤以5年随访结果为标准分成良恶性两组,其中良性组20例,恶性组15例。对良恶性组肿瘤间的核分裂数,核仁区嗜银蛋白(AgNOR)计数及增殖细胞核抗原(PCNA)进行研究。结果:PCNA在良恶性组肿瘤中均有表达,阳性率分别为70%(14/20)和80%(12/15),差异无统计学意义;瘤细胞的核分裂数,AgNOR表达及细胞增殖指数(PI)在良恶性组间的差异均有统计学意义(P<0.01);并且核分裂数,AgNOR与PI间有良好的相关性(r=0.64,0.86,P<0.01)。结论:血管外皮细胞瘤是一种增殖活性较高具有潜在恶性的肿瘤,细胞增殖活性检测是鉴别血管外皮细胞瘤良恶性的客观指标,且核分裂数AgNOR及PI在评价血管外皮细胞瘤的生物学行为上具有一致性。
Objective ：To study the relationship between the cell proliferation and prognosis in hemangiopercytomas （HPCs）. Methods：Thirty - five cases of PHCs were, in accordance with the five - year follow - up survey,divided into two groups ： a benign one of 25 cases and a milignant of 15 cases. The cell proliferous activity （ mitotic activity , AgNOR, PCNA ） expression of these tumors were studied in the benign and milignant. Results： The expression of PCNA in benign tumors was 70% （14/20） , and in malignant tumors was 80% （ 12/15 ） , but there was no significant diffenece between benign and malignant （ P 〉 0.05 ） ; The difference of mitosis between benign and malignant groups was significant（ P 〈 0.01 ） , and AgNOR and PI were the same （ P 〈 0.01 ） ; Mitosis and AgNOR of HPC had significant relation to PI （ r = 0.64, 0.86,P 〈 0.01 ）. Conclusion ： HPC is a tumor with high proliferous activity and potential variable malignancy. The cell proliferous activity is adopted to distinguish hemangiopericytoma＇s biologic behavior. Mitosis, AgNOR and PI are related to prognosis of patients with HPC.
出处
《南通大学学报（医学版）》
2006年第1期41-42,44,共3页
Journal of Nantong University(Medical sciences)
关键词
血管外皮细胞瘤
核仁区
嗜银蛋白
增殖细胞抗原
Hemangiopericytoma
Siver -staining nucleolar organizer region
proliferating cell nuelean antigen
