摘要
应用检测核仁组成区相关嗜银蛋白(AgNOR)染色方法,对胆囊粘膜上皮单纯增生15例、不典型增生12例及原发性胆囊癌38例进行细胞学研究。从中发现细胞核中AgNOR颗粒的多寡及大小对确定不典型增生和癌具有重要意义。不典型增生组和癌症组每个细胞核内AgNOR颗粒大小及平均数明显高于上皮增生组(P<0.01)。研究结果表明,检测核仁区AgNOR颗粒可使胆囊粘膜上皮不典型增生和癌诊断的判定更为客观。认为AgNOR技术作为组织病理学的辅助诊断技术应更广泛地运用于肿瘤研究。
Using a silver staining technique, nucleolar organizer region-associated proteins(AgNOR) have been studied in paraffin section of 15 simple hyperplasia, 12 atypical hyperplasia and 38 primary carcinoma of the gallbladder mucous epithelium. The results showed that the mean number and size of AgNOR per nucleus were of important significance in defining atypical hyperplasia and carcinoma. It was found in the present study that the mean number and size of AgNOR per nucleus in malignant gallbladder lesions significantly exceeded those of benign lesions.The results indicate that the mean number and size of AgNOR per nucleus can be used to differentiate atypical hyperplasia from carcinoma of gallbladder mucous epithelium more objectively. It is suggested that the AgNOR technique should be used more as an adjunct to diagnostic histopathology.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1991年第1期19-22,共4页
Medical Journal of Chinese People's Liberation Army
关键词
核仁区
嗜银蛋白
胆囊癌
诊断
AgNOR Primary carcinoma of the gallbladder Gallbladder
