摘要
目的:比较口腔粘膜癌变过程中核仁组织区(NOR)的变化及与癌变趋势的关系。方法:选取人正常及不同病变的口腔粘膜,采用胶体银染色法检测NOR,分析AgNOR的位置形态和AgNOR颗粒面积与核面积的比值。结果:正常口腔粘膜Ag-NOR颗粒主要见于上皮基底层,形态学分型为单一型;重度上皮异常增生以聚集型为主,部分为弥散型;口腔鳞状细胞癌主要为聚集型,部分为核仁内型。随着病变程度和异常增生程度加重,AgNOR颗粒面积与细胞核面积比值增加。结论:AgNOR表达在口腔粘膜癌变过程中逐渐增强。
Objective： To study the relation between nucleolar oryanizer regions （NOR） and the trend of carcinomatous changes during oral carcinogenesis. Methods： 6 normal human oral mucosa, 6 simple hyperplasia, 22 dysplasia,and and 7 oral squamous cell carcinoma cases were tested with the method of silver staining for the expression of NOR. Results： AgNOR was found to locate in the basal cell layer of normal mucosa, mainly in a single form. Most of the severe dysplasia express AgNOR in an aggregated form and some express AgNOR in a diffuse form.In most of the squamous cell carcinoma expressed AgNOR in aggregated form and some in inter-nucleolus form. Conclusion：The expression of AgNOR increases gradually during oral carcinogenesis.
出处
《泸州医学院学报》
2006年第2期98-99,共2页
Journal of Luzhou Medical College
