摘要
目的:通过观察孤立性纤维性肿瘤(SFT)和血管外皮瘤(HPC)的组织形态学特征和免疫组织化学表型,探讨二者之间的本质和相互联系。方法:对12例SFT和6例HPC进行临床病理分析、形态学观察和免疫组织化学染色的检测。结果:光镜下SFT具有大量疏密相间的梭形细胞、灶性血管外皮瘤样区域,并见较多胶原沉积及血管壁的透明变性。HPC肿瘤细胞单一,可见大量不规则分枝血管,呈鹿角状。12例SFT中,CD34和Bcl-2呈弥漫性强阳性(均为100%),CD99阳性率为75.00%。6例HPC中,CD99和Bcl-2为66.67%,CD34仅为16.77%。结论:两种肿瘤同属纤维母细胞/肌纤维母细胞肿瘤家族,在形态改变和免疫表型上有所重叠,但仍具有各自的病理形态特点,因此可分别视为独立的肿瘤类型。
Objective： To explore the nature and relationship between solitary fibrous tumor （SFT） and hemangiopericytoma （HPC） by morphologic and immunohistochemical observation. Methods： Twelve cases of SFT and 6 cases of HPC were analyzed by clinicopathologic study and immunohistochemical staining of CD34, CD99 and Bcl-2. Results： Histologically, SFF was composed of numerous spindle cells with variable cellularity, local hemangiopericytoma-like areas, scattered dense collagenization and perivascular hyalinization. HPC showed a monomorphic population with a branching ＂stag horn＂ vascular pattern. SFF exhibited diffuse positive for CD34 （100%）, Bcl-2 （100%）, and CD99 （75.00%）. HPC was positive for CD99 and Bcl-2 （both 66.67%）, but only 16.67% for CD34. Conclusion： Both SFY and HPC belong to the fibroblastic and myofibroblastic neoplasm category with histologic and immunohistochemical overlap, but the morphologic differences allow us to infer the 2 lesions constitute distinct entities.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2006年第11期644-647,共4页
Chinese Journal of Clinical Oncology
