摘要
以Ｃ５７ＢＬ／６Ｊ小鼠为模型，研究了甲巯咪唑（ＭＭＩ）对小鼠脾Ｔ淋巴细胞亚群及ＮＫ细胞杀伤活性的影响。结果表明，ＭＭＩ使小鼠血清中甲状腺素Ｔ３，Ｔ４水平明显降低，使脾Ｔ淋巴细胞中Ｌ３Ｔ４＋细胞数量显著减少、Ｔｈｙ１．２＋细胞和Ｌｙｔ２＋细胞数量降低、Ｌ３／Ｌｙｔ２比值下降。而且实验鼠脾ＮＫ细胞对腹水型Ｓ１８０靶细胞的细胞毒活性明显降低。表明ＭＭＩ对小鼠的细胞免疫有非特异的免疫抑制作用。
Effects of methimazole (MMI) on the spleen T lymphocytic subsets and NK cell cytotoxic aetivity in C57 BL/6J mouse model were studied. The following results were observed: 1. The level of serum thyroxine T3, T4 were markedly reduced that caused by MMI. 2. The number of L3T4+ cells in the splenic T lymphocyte was decreased. 3. The absolute number of Thy1.2+ and Lyt2+ cells was decreased and the relative ratio in both subsets was come down. It was also revealed that the cytotoxic activity of NK cells on the S180 target cells in ascitis tumour were distinct reduced.It was revealed that there was a nonspecific immunosuppressive effects on the experimenta1 mouse cellular immunity for the MMI.
出处
《山东医科大学学报》
1994年第1期28-30,共3页
Acta Academiae Medicinae Shandong
关键词
甲疏咪唑
T细胞
杀伤细胞
天然
Methimazole
Subsets, T lymphocytes
Killer cells, natural
Mice,inbred C_(57)BL
