摘要
本研究证实,S_(130)肉瘤(腹水型)、肝癌及CCl_4慢性中毒致免疫功能损伤的BALB/C小鼠均伴有血清T_3,T_4明显降低。用小剂量甲状腺片1.2(μg·g)/d治疗后,见血清T_3,T_4逐渐恢复,并伴有巨噬细胞-胸腺淋巴细胞受体活性变化、吞噬活性升高,脾NK细胞自然杀伤效应增强及溶血素抗体测定OD值增高等免疫指标的改变。表明小剂量甲状腺素对免疫损伤鼠及荷瘤鼠有免疫调节的生物活性作用。
This study has confirmed a phenomena that the impairment of immune function caused by S_(180)sarcoma,liver cancec and CCl_4 is rela-ted with the reduction of serum T_3,T_4.After treatment with small dosage
of thyroid Tab.(1.2μg·g/d),it was found that T_3,T_4 shown a normal level accompained a markedly raise of Mφ-ThyL receptor activity and phag-ocytic activity of Mφ.Also the natural killing effect of spleen NK cell of mice was enhanced as well as the raise of OD value of hemolytic anti-body and other immune index.It was demonstrated that thyroxine has an affirm effect of immunoregulation for tumor-bearing mice and immuno-injured mice.
出处
《山东医科大学学报》
1991年第4期292-295,297-298,共4页
Acta Academiae Medicinae Shandong
