摘要
目的 :探讨表皮生长因子 (EGF)、转化生长因子 α(TGF α)和表皮生长因子受体 (EGFR)在肝细胞癌 (HCC)发生、发展过程中的作用 .方法 :应用反转录 聚合酶链式反应 (RT PCR) .结果 :EGF在HCC ,癌旁和正常肝组织中表达率分别为95 .0 % ,91 .7%和 37.5 % ;TGF α在上述三种肝组织中的表达率分别为 85 .0 % ,83.3%和 2 5 .0 % ;而EGFR则分别为 95 .0 % ,1 0 0 %和 5 0 .0 % .EGF和EGFR在HCC中的表达率明显高于TGF α.结论 :HCC中存在着EGF/EGFR或 (和 )TGF α/EGFR自分泌系统 。
AIM: To investigate the roles of epidermal growth factor (EGF), transforming growth factor α(TGF α) and EGF receptor (EGFR) in the occurrence and development of hepatocellular carcinoma (HCC). METHODS: Reverse transcription polymerase chain reaction (RT PCR) was employed. RESULTS: The positivity rate of EGF in HCC, pericancerous and normal liver tissues was 95.0%, 91.7% and 37.5%, respectively, and the positivity rate of TGF α was 85.0%, 83.3% and 25.0%, respectively, whereas the positivity rate of EGFR was 95.0%, 100% and 50.0% respectively. EGF and EGFR had a higher expression level in HCC than TGF α. CONCLUSION: The autocrine system of EGF/EGFR and /or TGF α/EGFR exists in HCC, but the EGF/EGFR system may play a more important role in the proliferation and differentiation of HCC.
出处
《第四军医大学学报》
北大核心
2004年第9期833-835,共3页
Journal of the Fourth Military Medical University
关键词
肝细胞癌
表皮生长因子
转化生长因子-Α
表皮生长因子受体
逆转录-聚合酶链反应
hepatocellular carcinoma
epidermal growth factor
transforming growth factor-α
epidermal growth factor receptor
reverse transcription-polymerase chain reaction
