摘要
目的 :研究伴有静脉侵袭的结直肠癌组织中CD4 4mRNA的表达及其与肝转移的关系。方法 :采用反转录 -聚合酶链式反应 (RT -PCR)方法检测 31例伴有静脉侵袭的结直肠癌组织中CD4 4mRNA的表达状况。结果 :CD4 4mRNA在伴有静脉侵袭的结直肠癌组织中阳性表达率为 6 4 .5 %。同时伴有肝转移者 ,CD4 4mRNA的强阳性表达率为 70 .6 % ,表达强度明显高于无肝转移者 (2 8.6 % ) ,P <0 .0 1。结论 :结直肠癌组织中CD4 4mRNA具有较高的阳性表达率 。
Objective:To investigate the expression of CD44 mRNA in venous invasional colorectal cancer and its relationship with liver metastasis.Methods:Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to detect the expression of CD44 mRNA in 31 cases of venous invasional colorectal cancer.Results:The rate of positive expression of CD44 mRNA in colorectal cancer was 64.5%. In the cases of colorectal cancer with liver metastasis, the rate of strongly positive expression of CD44 mRNA were 70.6 %, significantly higher than that without liver metastasis ( P <0.01).Conclusion:Expression of CD44 mRNA in colorectal cancer is significantly correlated with the liver metastasis of colorectal cancer.
出处
《西北国防医学杂志》
CAS
2002年第6期426-428,共3页
Medical Journal of National Defending Forces in Northwest China
基金
国家自然科学基金资助项目 (3 0 0 70 741)
