摘要
D_对羟基苯甘氨酸 (D_p_HPG)是半合成青霉素和头孢霉素的重要前体。综述了微生物酶法生产D_对羟基苯甘氨酸的方法种类及其优缺点并对酶的来源即菌种的选育方法做了总结。此外 。
D-hydroxyphenylglycine was the most important precursor used for the synthesis of semisynthetic penicillin and cephalosporin.The microbial enzymatic synthesis of D-p-hydroxyphenylglycine were reviewed.The screening methods to obtain the strains which can produce D-hydantoinase and D-carbamoylase were introduced.Furthermore,the advances on genetic engineering were discussed.
出处
《生物学杂志》
CAS
CSCD
2003年第6期11-13,F003,共4页
Journal of Biology
