摘要
目的 :探讨高成瘤率兔VX2肝癌模型建立的方法及超声技术对肿瘤的监测。方法 :采用瘤块移植法建立起兔VX2肝癌模型 ,病理切片检查验证VX2瘤株在兔肝脏的成瘤情况 ;采用超声技术检测肝脏实质回声 ,肝内肿瘤的大小和回声变化 ,瘤内血管生成及变化情况以了解肿瘤的生长特征。结果 :采用瘤块移植法成功建立起稳定的兔VX2肝癌模型 ,成瘤率为10 0 % ;超声能准确测量肿瘤的大小 ,能实时、准确地监测肝内肿瘤的回声变化及肿瘤血管的分布情况。结论 :瘤块移植法是一种操作简单、成瘤率高的建立兔VX2肝癌模型的方法 ;超声技术能准确、方便、无创地监测肝脏肿瘤及肿瘤血管 ;采用超声影像技术对兔VX2肝癌生长特征的监测结果为临床利用该模型来评价诊治肝癌的新技术、新疗法的疗效提供了监测方法和参考指标。
Objective:To explore a method of high successful rate to establish the rabbit VX2 carcinoma model, and monitor the tumor with ultrasound technique.Methods:Tumor block transplanting method was used to make the rabbit VX2 carcinoma model,and verify the tumor in rabbit′s liver with pathological section.Ultrasound technique was applied to detect liver echo, size and echo of tumor,generation and changing of blood vessels in tumor and to find out the characters of the rabbit VX2 carcinoma.Results:The rabbit VX2 carcinoma model was made successfully with tumor block transplanting method, and the success rate was 100%.The ultrasound technique could measure the size of tumor exactly, and it could monitor the changes of the echo and tumor blood vessels in carcinoma exactly at the right time.Conclusion:Tumor block transplanting method is a simple method to make rabbit VX2 carcinoma model with high successful rate. The ultrasound technique is an accurate、convenient and non-invasive method to monitor the carcinoma and blood vessels in tumor.The results provide experimental evidence in evaluating the efficacy of new techniques and therapeutics for liver carcinoma.
出处
《重庆医科大学学报》
CAS
CSCD
2003年第5期585-587,611,共4页
Journal of Chongqing Medical University
关键词
兔
VX2肝癌
超声技术
Rabbit
VX2 carcinoma
Ultrasound technique
