摘要
目的 观察促动力中药合剂对肝硬化患者血浆内毒素及TNF -α水平的影响 ,为临床防治肝硬化肠源性内毒素血症提供依据。方法 选择肝硬化患者 2 0例 ,将其随机分为对照组及中药组 ,两组均予保肝治疗 ,中药组同时给予大腹皮、白术、砂仁、枳实 ,于治疗前及治疗 1周后分别测定患者血浆内毒素及TNF -α的水平。结果 治疗前肝硬化对照组及中药组患者内毒素及TNF -α的水平无明显差异 ,治疗后肝硬化中药组患者内毒素及TNF -α的水平均明显低于肝硬化对照组 (P <0 .0 5或 0 .0 1 ) ;治疗后肝硬化对照组及中药组内毒素及TNF -α的水平均较治疗前有明显下降 ,以中药组显著。结论 促动力中药合剂可减少肝硬化患者内毒素血症的发生 ,其机制可能与影响TNF -α有一定关系。
Objective It is to observe the effect of kinetogenic Chinese herb on endotoxin and TNF α in plasma of patients with cirrhosis. Methods 20 patients with cirrhosis were randomly divided into control group and Chinese herb group, and all were treated with routine method. Additionally, the Chinese herb group were treated with Areca Peel, Artractylic Lancea, Amomum and Immature Bitter Orange. Levels of endotoxin and TNF α in plasma of two groups were detected before treatment and one week after treatment. Results Levels of endotoxin and TNF α in two groups had no difference before treatment, while that in Chinese herb group were markedly lower than that in control group ( P <0.05 or P <0.01). And that in two groups, especially the Chinese herb group, significantly decreased. Conclusion Levels of endotoxin in plasma of patients with cirrhosis can be decreased by the kinetogenic Chinese herb, which mechanism maybe related to TNF α.
出处
《现代中西医结合杂志》
CAS
2003年第11期1127-1128,共2页
Modern Journal of Integrated Traditional Chinese and Western Medicine
