期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

喉鳞状细胞癌中VEGF、bFGF的表达与颈淋巴结转移关系的研究 被引量：2

The study of relationship between expression of VEGF and bFGF and cervical lymph node metastasis in laryngeal squamate cell carcinomas
暂未订购
导出
摘要 目的探讨喉鳞状细胞癌中血管生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)的表达与颈淋巴结转移的关系。方法应用细胞免疫荧光染色技术和流式细胞技术,对60例喉鳞状细胞癌组织细胞VEGF、bFGF的表达进行了定性和定量研究。结果颈淋巴结转移组VEGF的表达(FI=2.35±0.49)较非转移组(FI=1.86±0.57)呈高表达(P<O.01),VEGF与bFGF二者在喉鳞状细胞癌的表达呈正相关(r=0.346,P<0.01)。结论 VEGF在喉鳞状细胞癌的颈淋巴结转移中可能起一定作用,可作为判断颈淋巴结是否转移的参考指标。 Purpose To investigate its possible role of the expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in cervical lymph node metastasis in laryngeal squamate cell carcinomas( LSCC) . Methods The qualitative and quantitative stady of expression of VEGF and bFGF in 60 LSCC patients was made by flow cytometry and immunofluorecence method. Results A significant different ( P < 0.01) expression of VEGF was found between the patients with cervical lymph node metastasis(FI = 2.35 ± 0.49) and those without lymph node metastasis( FI = 1.86 ± 0.57); and expeession of VEGF was positively correlated with expression of bFGF in LSCC( r = 0.346, p < 0.01). Conclusion Expression of VEGF may play an important role and should be used as a reference marker in cervical lymph node metastasis from LSCC.
作者 王占龙 迟放鲁 胡俊兰 赵端力
机构地区 河北医科大学第四医院耳鼻咽喉-头颈肿瘤外科 复旦大学眼耳鼻喉科医院耳鼻喉科
出处 《中国眼耳鼻喉科杂志》 2002年第6期337-338,共2页 Chinese Journal of Ophthalmology and Otorhinolaryngology
基金 河北省2000年医学科学研究重点项目 项目号2k044
关键词 喉鳞状细胞癌 VEGF BFGF 表达 颈淋巴结转移 研究 laryngeal neoplasms lymph node metastasis vascular endothelial growth factor(VEGF) basic fibroblast growth factor(bFGF) immunoenzyme technics
分类号 R739.65 [医药卫生—肿瘤]
  • 相关文献

参考文献3

  • 1谭东兴,谢民强,邵春奎,李永平,林健贤.鼻咽癌中VEGF、bFGF的表达及其与颈淋巴结转移的关系[J].中国耳鼻咽喉颅底外科杂志,2001,7(2):91-94. 被引量：5
  • 2Shingu K, Sugenoya A, ltoh N, et al. Expression of basic fibroblast gwwth factor in thyroid disorders. World J Surg, 1994, 18 (4) : 500-505.
  • 3Neuehrist C, Quint C, Pammer A, et al. Vascular endothelial growth faetor(VEGF) and mierovessel density in squamous cell carcinoma of the larynx: an immunohistochemical study. Acta Otolaryngol (Stockh),1999,119(6) :732-738.

二级参考文献8

  • 1[1]Takahaski Y, Kitadai Y, Bucana CD, et al. Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer[J]. Cancer Res,1995, 55: 3964～3968.
  • 2[2]Ohta Y, Watanabe Y, Murakami S, et al. Vascular endothelial growth factor and lymph node metastasis in primary lung cancer [J]. Br J Cancer, 1997, 76(8): 1041～1045.
  • 3[3]Shingu K, Sugenoya A, Itoh N, et al. Expression of basic fibroblast growth factor in thyroid disorders[J]. World J Surg, 1994,18(4): 500～505.
  • 4[4]Uchida S, Shimada Y, Watanabe G, et al. In oesophageal squamous cell carcinoma vascular endothelial growth factor is associated with p53 mutation, advanced stage and poor prognosis[J ]. Br J Cancer, 1998, 77(10): 1704～1709.
  • 5[5]Roychowdhury DF, Tseng A Jr, Fu KK, et al. New prognostic factors in nasopharyngeal carcinoma. Tumor angiogenesis and CerbB2 expression[J]. Cancer, 1996, 77(8): 1419～1426.
  • 6[6]Wakisaka N, Wen QH, Yoshizaki T, et al. Association of vascular endothelial growth factor expression with angiogenesis and lymph node metastasis in nasopharyngeal carcinoma[J]. Laryngoscope, 1999, 109: 810～814.
  • 7[7]Li D, Bell J, Brown A, et al. The observation of angiogenin and basic fibroblast growth factor gene expression in human colonic adenocarcinomas, gastric adenocarcinomas and hepatocellular carcinomas[J]. J Pathol, 1994, 172(2): 171～175.
  • 8[8]Goto F, Goto K, Weindel, et al. Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formatin of bovine capillarry endothelial cells within collagen gels[J]. Lab Invest, 1993, 69(5): 508～17.

共引文献4

同被引文献12

  • 1Weidner N. New paradigm for vessel intravasation by tumor cells[J]. Am J Pathol.2002.60(6):1937-1939.
  • 2Koh TY, Park SW, Park KH, et al. Inhibitory effect of p27KIP1 gene transfer on head and neck squamous cell carcinoma celt lines[J].Head Neck,2003,25(1 ) : 44-49.
  • 3Agui T, Mcconkey DJ. Tonigawa N. Comparative study of various biological paramerets, including expression of surviving. between primary and metastatic human colonic adenocarcinomas[J].Anticancer Res,2002 22(3).1769-1776.
  • 4Jesione K, Kupnicka D, Tenderenda M, et al. Extent of spontaneous apoptosis in gastric cancer relation to proliferative index p53 expression CD34 expression and histopathological features[J].J Exp Clin Cancer Res.2002.21(3):371-375.
  • 5Karpanen T, Egeblad M, Karkkainen MJ, et al. Vascular endothelial growth factor-C promotes lymphangiogenisis and intralymphatic tumor growth. Cancer Res,2001,61(5) : 1786-1790.
  • 6Yonemura Y, Endo Y, Fujita H, et al. Role of vascular endothelial growth factor C espression in the development of lymph node metastasis in gastric cancer. Clin Cancer Res, 1999,5(7) : 1823-1829.
  • 7Mattila MM, Ruohola JK, Karpanen T, et al. VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors. Int J Cancer,2002,98(6):946-951.
  • 8Beasly NJ, Prevo R, Banerji S, et al. Intratumoral lymphangiogenesis and lymph node metastasis in head and neck cancer. Cancer Res, 2002.62(5) : 1315-1320.
  • 9Padera TP, Kadambi A, Tomaso ED, et al. Lymphatic metastasis in the absence of fiunctional intratumor lymphatics. Science, 2002, 296 ( 7 ) :1883-1886.
  • 10Makinen T, Jussila L, Veikkola T, et al. Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3. Nat Med. 2001,7(2 ) : 199-205.

引证文献2

二级引证文献2

中国眼耳鼻喉科杂志
2002年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部