摘要
目的 :探讨高血压病动脉平滑肌组织端粒酶活性与高血压的发病关系。方法 :采用PCR -ELISA法检测 30例高血压病患者和 2 0例血压正常者肠系膜动脉平滑肌细胞 (SMC)端粒酶活性。结果 :高血压患者端粒酶阳性表达 2 8例 (93.3% )。血压正常者端粒酶阳性表达 3例 (15 % )。差异非常显著 (P <0 .0 5 )。结论 :高血压病动脉平滑肌细胞端粒酶活性的表达升高 ,可能与高血压发病有关。
Objective: To study the significance of telomerase activity in arteria smooth muscle tissue of hypertension. Methods: PCR-ELISA was applied to detect semiquantitatively the telomerase activity in 30 cases of hypertension and 20 cases of normal blood pressure. Results: Positive rate of telomerase activity was 93.3%(28/30)in hypertensive group and 15%(3/20) in normal group. The difference was significant (P<0.05). Conclusion: Telomerase activity expression of hypertension was higher than that of normal subjects in arteria smooth muscle cell of hypertension. Telomerase activity may be related with hypertension in episode.
出处
《泸州医学院学报》
2003年第1期10-11,共2页
Journal of Luzhou Medical College
