摘要
原发性干燥综合征(pSS)是一种复杂的致残性疾病,可导致长期的生活质量下降和多系统损害。目前,其发病机制主要涉及遗传因素、环境因素以及固有免疫与适应性免疫系统异常激活,通过自身抗体与免疫复合物沉积导致全身多器官、多系统病变。目前针对pSS的大多数治疗为对症治疗,在预防腺体损伤和抑制全身疾病活动方面疗效有限。因此,探索针对pSS的各种靶向治疗尤为重要,且早期发现并进行及时治疗对遏制pSS进展及改善患者预后有重要意义。
Primary Sjogren's syndrome(pSS)is a complex and disabling disease that leads to long-term deterioration in quality of life and multisystem damage.Currently it's known that the pathogenesis primarily involves genetic factors,environ mental influences,and dysregulated activation of the innate and adaptive immune systems,resulting in systemic multi-organ and multi-system lesions through autoantibodies and immune complex deposition.Most existing treatments for pSS are symp tomatic and offer limited efficacy in preventing glandular damage and suppressing systemic disease activity.Therefore,explo ring various targeted therapies for pSS is particularly crucial,and early detection and timely treatment are crucial for slowing Corresponding author:ZHANG Shurong,Email:zsr66@126.com the progression of pSS and improving the patient prognosis.
作者
高官莉
魏晓龙
周宏娅
申东北
张树荣
GAO Guanli;WEI Xiaolong;ZHOU Hongya;SHEN Dongbei;ZHANG Shurong(Department ofGastroenterology,Clinical College of Kunming Medical University/PLA 920th Hospital of Joint Logistics Support Force,Kunming 650032,China)
出处
《医学综述》
2025年第21期2633-2637,共5页
Medical Recapitulate
基金
云南省科技厅科技计划项目(202201AY070001-283)。
