摘要
目的 探讨CD44v6mRNA及其蛋白表达与胃癌预后的关系。方法 应用催化信号放大系统原位杂交和免疫组织化学技术,对17例早期胃癌、21例中期胃癌和57例晚期胃癌组织进行CD44v6mRNA及其蛋白检测。结果在胃癌中,CD44v6 mRNA及其蛋白的表达阳性率分别为85.3％和82.1％。CD44v6 mRNA及其蛋白表达阳性率在晚期胃癌明显高于早、中期胃癌(P<0.05)。CD44v6mRNA表达及其蛋白表达均与胃癌浆膜浸润、淋巴结转移和患者预后呈正相关(P<0.05)。结论 CD44v6 mRNA及其蛋白表达可反映胃癌分化不良或晚期阶段,可作为预测预后的客观指标。
Objective To investigate the relationship between the expression of CD44v6 mRNA and its protein,and prognosis of gastric carcinoma ( GC) . Methods Catalyzed signal amplification ( CSA ) in situ hybridization and immnohistochemistry were used to detect the expressions of CD44v6 mRNA and its protein in 95 cases of GC ( 17 early stage,21 metaphasc and 57 advanced cases). Results The positive rates of CD44v6 mRNA and its protein in GC was 85.3% and 82. 1% respectively. Expressions of CD44v6 mRNA and its protein were significantly higher in advanced GC than those in early stage and melaphase oi GC ( P < 0. 05 ) . Moreover. CD44v6 mRNA was expressed consistently with its protein and both of them were positively correlated with serous infiltration.lymphatic metastasis and the prognosis of GC ( P < 0. 05 ). Conclusions The expressions of CD44v6 mRNA and its protein might serve as indicators to show- a poor differentiation or advanced GC and as objective markers to evaluate prognosis of patients with GC.
出处
《华北国防医药》
2002年第4期237-239,I002,共4页
Medical Journal of Beijing Military Region
