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miR-181a调控结肠癌细胞生长的作用和机制研究 被引量:6

Role of miR-181a in regulating colon cancer cell growth and the related mechanism
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摘要 结肠癌是指结肠黏膜上皮在环境或遗传等多种致癌因素作用下发生的恶性病变,是常见的恶性肿瘤之一,占所有恶性肿瘤的10%~15%^[1]。结肠癌的发病原因与遗传、结肠腺瘤、息肉病、慢性炎症、高脂肪、少纤维饮食习惯等都有一定关系^[2],结肠癌发病隐匿,病程慢早期无明显的临床表现,出现明显症状时大多已到了中晚期,病死率仅次于肺癌和肝癌,是危害人们健康的可怕杀手^[3]。
出处 《第二军医大学学报》 CAS CSCD 北大核心 2014年第5期574-576,共3页 Academic Journal of Second Military Medical University
基金 中国博士后科学基金(2013M542436)~~
关键词 miR-181a 结肠肿瘤 细胞增殖 PRKCD 肿瘤基因表达调控 miR-181a colonic neoplasms cell proliferation PRKCD neoplastic gene expressionregulation
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参考文献15

  • 1Watson A J,Collins P D.Colon cancer:a civilization disorder[J].Dig Dis,2011,29:222-228.
  • 2Pino M S,Chung D C.The chromosomal instability pathway in colon cancer [J].Gastroenterology,2010,138:2059-2072.
  • 3Klampfer L.Cytokines,inflammation and colon cancer [J].Curr Cancer Drug Targets,2011,11:451-464.
  • 4Hutchison E R,Kawamoto E M,Taub D D,Lal A,Abdelmohsen K,Zhang Y,et al.Evidence for miR-181 involvement in neuroinflammatory responses of as-trocytes[J].Glia,2013,61:1018-1028.
  • 5Vasilatou D,Papageorgiou S,Pappa V,Papageorgiou E,Dervenoulas J.The role of microRNAs in normal and malignant hematopoiesis [J].Eur J Haematol,2010,84:1-16.
  • 6Kim C H,Kim H K,Rettig R L,Kim J,Lee E T,Aprelikova O,et al.miRNA signature associated with outcome of gastric cancer patients following chemother-apy[J].BMC Med Genomics,2011,4:79.
  • 7Nishimura J,Handa R,Yamamoto H,Tanaka F,Shi-bata K,Mimori K,et al.MicroRNA-181a is associated with poor prognosis of colorectal cancer[J].Oncol Rep,2012,28:2221-2226.
  • 8Pekarsky Y,Santanam U,Cimmino A,Palamarehuk A,Efanov A,Maximov V,et al.Tell expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181[J].Cancer Res,2006,66:11590-11593.
  • 9Naguibneva I,Ameyar-Zazoua M,Polesskaya A,Ait-Si-Ali S,Groisman R,Souidi M,et al.The mieroRNA miR-181 targets the homeobox protein Hox-All during mammalian myoblast differentiation[J].Nat Cell Biol,2006,8:278-284.
  • 10Dahlhaus M,Sehult C,Lange S,Freund M,Junghan-ss C.MicroRNA 181a influences the expression of HMGB1 and CD4 in acute leukemias[J].Anticancer Res,2013,33:445-452.

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