摘要
目的:分析食管癌患者血清中VEGF-C含量检测及其与肿瘤分期、淋巴结转移、癌细胞活力的相关性。方法:112例在河北省唐山市丰润区第二人民医院接受治疗的食管癌患者作为观察组患者,同期在本院接受体检的健康者98例作为对照组,对比两组患者的血清VEGF-C含量,分析VEGF-C水平与肿瘤分期、淋巴结转移、癌细胞活力的相关关系。结果:观察组患者的血清VEGF-C含量高于正常对照组(P<0.05);血清SCC、CEA、CA199、CA125、CA50等肿瘤标志物水平值均高于正常对照组(P<0.05);食管癌患者的血清VEGF-C水平与肿瘤分期、淋巴结转移、癌细胞活力均呈正相关关系(P<0.05)。结论:食管癌患者的血清VEGF-C含量与其肿瘤分期、淋巴结转移、癌细胞活力等均存在良好的相关关系,定期检测VEGF-C水平可以成为评价治疗效果、预测治疗结局等的有效手段。
Objective：To analyze serum VEGF-C content in patients with esophageal cancer and its correlation with tumor stage,lymph node metastasis and cancer cell viability.Methods：A total of 112 patients with esophageal cancer treated in our hospital were selected as observation group,healthy subjects receiving physical examination in our hospital during the same time were selected as control group,serum VEGF-C content was compared between two groups of patients,and the correlation between VEGF-C level and tumor stage,lymph node metastasis as well as cancer cell viability was analyzed.Results：Serum VEGF-C level of observation group was significantly higher than that of normal control group（P〈0.05）;serum tumor markers SCC,CEA,CA199,CA125 and CA50 levels were significantly higher than those of normal control group（P〈0.05）;serum VEGF-C level of patients with esophageal cancer was positively correlated with tumor stage,lymph node metastasis and cancer cell viability（P〈0.05）.Conclusions：Serum VEGF-C content in patients with esophageal cancer is well correlated with tumor stage,lymph node metastasis and cancer cell viability,and regular detection of VEGF-C level can be the effective means to evaluate the therapeutic effect and predict treatment outcome.
出处
《海南医学院学报》
CAS
2017年第2期155-157,161,共4页
Journal of Hainan Medical University
基金
河北省科技厅支撑计划项目(H2013100061)~~
