摘要
目的评价血管内皮生长因子(vascular endothelial growth factor,VEGF)基因+936C/T位点单核苷酸多态性(single nucleotide polymorphism,SNP)与乳腺癌易感性的关系。方法检索PubMed、EMBASE、Cochrane图书馆、中国生物医学文献数据库(CBM),获取有关VEGF基因多态性与乳腺癌易感性的病例-对照研究,按照纳入、排除标准选择文献、并从纳入文献中提取相关数据,以病例组和对照组基因型分布的比值比(OR)为效应指标,应用Stata12.0软件以不同合并模型对各研究原始数据进行Meta分析。结果 VEGF基因+936C/T位点共纳入10项研究,累计病例8752例,对照8961例,合并分析结果:加性模型T vs.C:OR(95%CI)=0.90(0.81～0.99);共显性模型CT vs.CC:OR(95%CI)=0.88(0.78～0.90,TT vs.CC:OR(95%CI)=0.91(0.74～1.12);显性模型TT+CT vs.CC:OR(95%CI)=0.88(0.78～0.99);隐形模型TT vs.CT+CC:OR(95%CI)=0.93(0.76～1.15)。结论 VEGF基因+936C/T位点多态性与乳腺癌的易感性有关,T等位基因可能降低乳腺癌的发病风险。
Objective To explore the relationship between the polymorphism of VEGF and genetic susceptibility of breast cancer. Methods References were retrieved in PubMed, EMBASE, the Cochrane library, Chinese Biological Medicine Disk.Odds ratio （OR） with 95% confidence interval （CI） was used to assess the strength of this association. All analyses were conducted in Stata12.0. Results A total of 10 case-control studies with 17 713 subjects on VEGF＋936C/T were included in this Meta- analysis, significant decreased risks were found in allele model T vs. C： OR（95%CI）=0.90（0.81-0.99）; co-dominant model CT vs. CC：OR （95%CI ）=0.88（0.78-0.90）, TT vs. CC： OR（95%CI）=0.91（0.74-1.12）; dominant model TT＋CT vs. CC： OR（95%CI ）=0.88 （0.78-0.99）;recessive model TT vs. CT＋CC： OR（95%CI）=0.93 （0.76～1.15） .Conclusion ＋936C/T polymorphism of the VEGF gene is associated with breast cancer, T allele may be a rotective factor.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2013年第5期489-494,共6页
Cancer Research on Prevention and Treatment
关键词
血管内皮生长因子
单核苷酸多态性
乳腺癌
META分析
Vascular endothelial growth factor （VEGF）
Single nucleotide polymorphism
Breast cancer
Meta-analysis
